Taylor Darlene K, Leppert Phyllis C
Department of Chemistry, North Carolina Central University, 3105 M. Townes Science Building, 1801 Concord Street, Durham, NC 27707, United States ; Departments of Obstetrics and Gynecology and Pathology, Duke University School of Medicine, 242 Sands Building, Box 103206, Durham, NC 27710, United States.
Drug Discov Today Ther Strateg. 2012;9(1):e41-e49. doi: 10.1016/j.ddstr.2012.06.001.
Uterine fibroids are common reproductive-age benign tumors that contribute to severe morbidity and infertility. Cumulative incidence is 4 times higher in Africian-Americans compared to Caucasians and constitutes a major health disparity challenge. Fibroids are the leading indication for hysterectomy and their management averages $21 billion annually in the US. No long term minimally invasive therapies exist. Thus, promising drug therapies, their chemistry, pharmacology, and clinical efficacy, focusing first on innovative drug delivery approaches, are reviewed.
子宫肌瘤是常见的育龄期良性肿瘤，会导致严重的发病率和不孕症。与白种人相比，非裔美国人的累积发病率高出4倍，这构成了一项重大的健康差异挑战。子宫肌瘤是子宫切除术的主要指征，在美国，其治疗费用平均每年达210亿美元。目前尚无长期的微创治疗方法。因此，本文综述了有前景的药物治疗方法，包括其化学、药理学和临床疗效，首先聚焦于创新的药物递送方法。
