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直立性低血压、糖尿病与老年患者跌倒:一项横断面研究。

Orthostatic hypotension, diabetes, and falling in older patients: a cross-sectional study.

机构信息

Diabetes Centre, Isala Clinics, Zwolle, The Netherlands.

出版信息

Br J Gen Pract. 2012 Oct;62(603):e696-702. doi: 10.3399/bjgp12X656838.

DOI:10.3399/bjgp12X656838
PMID:23265229
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3459777/
Abstract

BACKGROUND

Although orthostatic hypotension (OH) is more prevalent in old age, and in patients with diabetes, the prevalence of OH in older patients with type 2 diabetes mellitus is unknown.

AIM

To establish the prevalence of OH, and its association with falling, in home-dwelling older participants with and without type 2 diabetes.

DESIGN AND SETTING

A cross-sectional study in primary care in the Netherlands.

METHOD

A total of 352 patients with type 2 diabetes, and 211 without participated in this study. OH was defined as a fall in blood pressure of at least 20 mmHg systolic or 10 mmHg diastolic after either 1 or 3 minutes in an upright position. Feelings of dizziness, light-headedness, or faintness during the standing period were documented as orthostatic complaints. Fall risk was assessed with a validated risk profile instrument.

RESULTS

The prevalence of OH was 28% (95% CI = 24% to 33%) and 18% (95% CI = 13% to 23%) in participants with and without type 2 diabetes, respectively. OH was not related to falling, while the presence of orthostatic complaints in itself was associated with both previous fall incidents as well as a high fall risk, even after adjustment for OH. The adjusted odds ratios were 1.65 (95% CI = 1.00 to 2.72) and 8.21 (95% CI = 4.17 to 16.19), respectively.

CONCLUSION

OH is highly prevalent in home-dwelling older people with and without type 2 diabetes. Those with orthostatic complaints had an increased risk for falling, whereas those with OH were not.

摘要

背景

虽然直立性低血压(OH)在老年和糖尿病患者中更为常见,但 2 型糖尿病老年患者中 OH 的患病率尚不清楚。

目的

确定 2 型糖尿病和非 2 型糖尿病的居家老年患者中 OH 的患病率及其与跌倒的关系。

设计和设置

荷兰初级保健中的横断面研究。

方法

共有 352 名 2 型糖尿病患者和 211 名非 2 型糖尿病患者参加了这项研究。OH 的定义为在直立位 1 或 3 分钟后血压至少下降 20 mmHg 收缩压或 10 mmHg 舒张压。在站立期间记录头晕、头晕或晕厥的感觉作为直立性投诉。使用经过验证的风险评估工具评估跌倒风险。

结果

患有和不患有 2 型糖尿病的参与者中 OH 的患病率分别为 28%(95%CI = 24%至 33%)和 18%(95%CI = 13%至 23%)。OH 与跌倒无关,而直立性投诉本身与既往跌倒事件以及高跌倒风险相关,即使在调整 OH 后也是如此。调整后的优势比分别为 1.65(95%CI = 1.00 至 2.72)和 8.21(95%CI = 4.17 至 16.19)。

结论

患有和不患有 2 型糖尿病的居家老年患者中 OH 患病率很高。有直立性投诉的患者跌倒风险增加,而有 OH 的患者则没有。

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