Murthy K K, Calnek B W
Avian Dis. 1979 Oct-Dec;23(4):831-7.
The appearance of MATSA-bearing cells in the spleens of genetically susceptible (P-line) and resistant (N-line) chickens followed similar patterns at 4 and 6 days postinoculation (PI), with 4 to 10% of the cells positive in indirect fluorescent-antibody tests. Levels of MATSA-positive cells at 10, 14, and 21 days PI continued at 6-8% in P-line birds but dropped from about 8% to below 1 or 2% in N-line birds. This pattern was seen also in virus-isolation rates from the same spleen samples. Viral internal antigens (VIA) were seen equally and with decreasing incidence in both groups at 4-10 days PI. VIA were not detected at 14 days but reappeared at 21 days, with higher levels in P-lines than inN-lines. It was concluded that genetic resistance to Marek's disease is not related to events which result in production of the putative tumor antigen, MATSA, but rather to host-controlled factors which terminate those events.
在接种后4天和6天，遗传易感性（P系）和抗性（N系）鸡脾脏中携带MATSA的细胞出现模式相似，间接荧光抗体试验中有4%至10%的细胞呈阳性。接种后10天、14天和21天，P系鸡中MATSA阳性细胞水平持续保持在6%至8%，但N系鸡中该水平从约8%降至1%或2%以下。相同脾脏样本的病毒分离率也呈现出这种模式。接种后4至10天，两组中病毒内部抗原（VIA）出现情况相同且发生率逐渐降低。14天时未检测到VIA，但在21天时重新出现，P系中的水平高于N系。得出的结论是，对马立克氏病的遗传抗性与导致假定肿瘤抗原MATSA产生的事件无关，而是与终止这些事件的宿主控制因素有关。
