Patel J R, Edington N, Mumford J A
Arch Virol. 1982;74(1):41-51. doi: 10.1007/BF01320781.
Subtype-1 isolates of Equine herpesvirus-1 (EHV-1) from a quadriplegic horse and from an aborted foetus were compared with each other and with a subtype-2 respiratory isolate. All 3 isolates were detected in the epithelium and macrophages of the respiratory tract. Both the paresis and foetal subtype-1 isolates replicated in the epithelium of the ileum and this correlated with the recovery of virus from faeces in vivo. The paresis subtype-1 isolate also had a predelection for vascular endothelial cells, particularly in the nasal mucosa, but also in the lungs, central nervous system, adrenal and thyroid. In the 9 foals inoculated with the paresis isolate two developed hind limb dysfunction, four developed diarrhoea, and one of these 4 died with an intussusception. The differences between these isolates are discussed in relation to other herpesviruses.
将一匹四肢瘫痪马和一个流产胎儿身上分离出的1型马疱疹病毒（EHV-1）毒株，与一株2型呼吸道分离株进行了相互比较。在所有3株分离株的呼吸道上皮细胞和巨噬细胞中均检测到病毒。轻瘫和胎儿1型分离株均可在回肠上皮细胞中复制，这与体内粪便中病毒的检出情况相关。轻瘫1型分离株还特别倾向于感染血管内皮细胞，尤其是鼻黏膜中的血管内皮细胞，但肺部、中枢神经系统、肾上腺和甲状腺中的血管内皮细胞也会被感染。在接种了轻瘫分离株的9只幼驹中，2只出现后肢功能障碍，4只出现腹泻，其中1只因肠套叠死亡。结合其他疱疹病毒对这些分离株之间的差异进行了讨论。
