Murthy K K, Calnek B W
J Natl Cancer Inst. 1978 Sep;61(3):849-54.
Marek's disease tumor-associated surface antigen (MATSA) appeared in different lymphoid tissues of P-line chickens soon after they were infected with BC-1 strain of Marek's disease virus. MATSA-bearing cells first appeared in spleens by 5 days post infection (PI) and were observed through a 21-day experimental period at mean levels varying from 3.8 to 21.9% of the total cells examined. Lower percentages of MATSA-bearing cells were observed in the thymus, in the bursa of Fabricius, among peripheral blood lymphocytes, and among bone marrow cells beginning 7 days PI. The antigen was not detected on normal lymphocytes from chickens or chicken embryos, nor was it detected on cultured chicken embryo fibroblasts infected or transformed by avian RNA tumor viruses.
马立克氏病肿瘤相关表面抗原（MATSA）在P系鸡感染马立克氏病病毒BC-1株后不久便出现在其不同的淋巴组织中。携带MATSA的细胞在感染后5天（PI）首先出现在脾脏中，并在整个21天的实验期内均有观察到，其平均水平占所检测细胞总数的3.8%至21.9%。从感染后7天开始，在胸腺、法氏囊中、外周血淋巴细胞以及骨髓细胞中观察到携带MATSA细胞的比例较低。在来自鸡或鸡胚的正常淋巴细胞上未检测到该抗原，在感染或被禽RNA肿瘤病毒转化的培养鸡胚成纤维细胞上也未检测到该抗原。
