Poh Rozaida, Muniandy Sekaran
Department of Molecular Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
Southeast Asian J Trop Med Public Health. 2010 Sep;41(5):1231-46.
The role of paraoxonase 1 in cardiovascular disease complications in type 2 diabetes mellitus is not fully understood. We studied paraoxonase activity towards paraoxon in 188 non-diabetic and 140 diabetic subjects using general linear models and univariate analysis. Adjusting for age revealed a reduction in activity towards paraoxon was associated with a significant increase in risk (p = 0.023) for cardiovascular disease complications in diabetic patients. Multivariate analysis of two plasma measures of paraoxonase activity using paraoxon and diazoxon also showed reduced paraoxonase activity towards paraoxon was associated with a significant increase in risk (p = 0.045) for cardiovascular disease complications in diabetic patients. These analyses showed that a reduced paraoxonase activity towards paraoxon was associated with ethnicity. Based on multivariate analysis, subjects of Malay ethnic origin have significantly higher than expected activity (p = 0.008, compared to Indians), towards paraoxon than subjects of Chinese origin who in turn had higher than expected paraoxonase activity (p = 0.028, compared to Indians) Indian subjects.
对氧磷酶1在2型糖尿病心血管疾病并发症中的作用尚未完全明确。我们运用一般线性模型和单因素分析，研究了188名非糖尿病患者和140名糖尿病患者针对对氧磷的对氧磷酶活性。校正年龄后发现，糖尿病患者中对氧磷酶对氧磷的活性降低与心血管疾病并发症风险显著增加相关（p = 0.023）。使用对氧磷和重氮苯磺酸对两种血浆对氧磷酶活性指标进行多因素分析，结果也显示糖尿病患者中对氧磷酶对氧磷的活性降低与心血管疾病并发症风险显著增加相关（p = 0.045）。这些分析表明，对氧磷酶对氧磷的活性降低与种族有关。基于多因素分析，马来族裔受试者对氧磷酶对氧磷的活性显著高于预期（与印度人相比，p = 0.008），而华裔受试者的对氧磷酶活性高于预期（与印度人相比，p = 0.028），印度受试者的对氧磷酶活性则低于预期。
