Malmström Vivianne, Venalis Paulius, Albrecht Inka
Arthritis Res Ther. 2012 Dec 28;14(6):230. doi: 10.1186/ar4116.
T cells of both the CD4 and CD8 lineage are commonly found in affected tissues of patients with idiopathic inflammatory myopathies, but understanding the contribution of these cells to immunopathogenesis remains challenging. Given recent advances in identifying more myositis-associated autoantibodies and their putative targets, we suggest that studies on autoreactive T cells targeting those autoantigens are one way forward. Another (so far, more frequently used) approach comes from studies on effector T cells in the context of myositis. This review summarizes recent advances and current hypotheses in both of these contexts.
在特发性炎性肌病患者的受累组织中通常可发现CD4和CD8谱系的T细胞，但了解这些细胞在免疫发病机制中的作用仍然具有挑战性。鉴于在鉴定更多与肌炎相关的自身抗体及其假定靶点方面的最新进展，我们认为针对这些自身抗原的自身反应性T细胞研究是一条前进的道路。另一种（迄今为止更常用的）方法来自于在肌炎背景下对效应T细胞的研究。本综述总结了这两种情况下的最新进展和当前假说。
