Hospices Civils de Lyon, Centre National de Référence des Staphylocoques, Bron, France.
PLoS One. 2012;7(12):e51172. doi: 10.1371/journal.pone.0051172. Epub 2012 Dec 13.
Staphylococcus aureus isolates from two prospective studies on infective endocarditis (IE) conducted in 1999 and 2008 and isolated from non-IE bacteremia collected in 2006 were spa-typed and their virulence factors were analyzed with a microarray. Both populations were genetically diverse, with no virulence factors or genotypes significantly more associated with the IE isolates compared with the non-IE isolates. The population structure of the IE isolates did not change much between 1999 and 2008, with the exception of the appearance of CC398 methicillin-susceptible Staphylococcus aureus (MSSA) isolates responsible for 5.6% of all cases in 2008. In 1999, this lineage was responsible for no cases. The increasing prevalence of S. aureus in IE is apparently not the result of a major change in staphylococcal population structure over time, with the exception of the emerging CC398 MSSA lineage.
从 1999 年和 2008 年进行的两项感染性心内膜炎（IE）前瞻性研究中分离的金黄色葡萄球菌分离株，以及 2006 年从非 IE 菌血症中分离的金黄色葡萄球菌分离株，进行 spa 型分型，并使用微阵列分析其毒力因子。两个群体的遗传多样性都很高，与非 IE 分离株相比，没有任何毒力因子或基因型与 IE 分离株显著相关。IE 分离株的种群结构在 1999 年至 2008 年间变化不大，除了 2008 年出现了占所有病例 5.6%的 CC398 型甲氧西林敏感金黄色葡萄球菌（MSSA）分离株外。1999 年，该谱系没有引起任何病例。金黄色葡萄球菌在 IE 中的流行率增加，显然不是由于一段时间内葡萄球菌种群结构的重大变化所致，除了新兴的 CC398 MSSA 谱系。
