一种使用 SPECT 对脑疾病组与正常对照组进行半定量相关分析的方法：阿尔茨海默病与血管性痴呆。
A semi-quantitative method for correlating brain disease groups with normal controls using SPECT: Alzheimer's disease versus vascular dementia.
机构信息
University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, United States.
出版信息
Comput Med Imaging Graph. 2013 Jan;37(1):40-7. doi: 10.1016/j.compmedimag.2012.11.001. Epub 2012 Dec 27.
PURPOSE
To demonstrate the utility of semi-quantitative circumferential-profile analysis of regional cerebral blood flow (rCBF) SPECT in Alzheimer's disease (AD) versus white matter vascular dementia (WM-VaD).
METHODS
Subjects underwent dementia evaluation, MRI and Tc-99m HMPAO SPECT. rCBF patterns from 11 AD and 20 WM-VaD patients were compared to 17 controls using semi-quantitative circumferential-profile analysis.
RESULTS
AD patients showed more significant semi-quantitative circumferential-profile reductions in the posterior temporo-parietal regions, whereas WM-VaD patients demonstrated greater reductions involving the frontal regions of the brain.
CONCLUSION
Semi-quantitative circumferential-profile analysis provides a practical semi-quantitative method to evaluate brain SPECT scans in AD versus WM-VaD patients.
目的
展示半定量周向轮廓分析在阿尔茨海默病（AD）与脑白质血管性痴呆（WM-VaD）中的区域脑血流（rCBF）SPECT 的应用。
方法
受试者接受痴呆评估、MRI 和 Tc-99m HMPAO SPECT 检查。使用半定量周向轮廓分析，将 11 名 AD 患者和 20 名 WM-VaD 患者的 rCBF 模式与 17 名对照进行比较。
结果
AD 患者在后颞顶叶区域表现出更显著的半定量周向轮廓减少，而 WM-VaD 患者则表现出更大程度的额叶区域减少。
结论
半定量周向轮廓分析为评估 AD 与 WM-VaD 患者的脑 SPECT 扫描提供了一种实用的半定量方法。
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