兔颈总动脉模型在超声溶栓研究中的应用。
Introduction of a rabbit carotid artery model for sonothrombolysis research.
机构信息
Brain Ultrasound Research Laboratory (BURL), Department of Radiology, University of California San Diego, 200 West Arbor Drive, San Diego, CA 92103-8756, USA.
出版信息
Transl Stroke Res. 2012 Sep;3(3):397-407. doi: 10.1007/s12975-012-0194-5. Epub 2012 Jun 22.
Abstract
The goal of this study was to develop an in vivo sonothrombolysis model for stroke research. The rabbit carotid artery has average vessel diameters similar to human M1/M2 segments and allows generation of a thrombotic occlusion using various kinds of thrombus material as well as thrombus placement under visual control. It further allows real-time monitoring of flow and clot mechanics during the sonothrombolysis procedure using high-frequency diagnostic ultrasound. In the present study, the model will be introduced and first results to show feasibility using diagnostic as well as high-intensity focused ultrasound will be presented.
摘要
本研究旨在建立一种用于卒中研究的体内超声溶栓模型。兔颈总动脉的平均血管直径与人脑中动脉 M1/M2 段相似，可通过使用各种血栓材料以及在可视控制下放置血栓来形成血栓闭塞。它还允许使用高频诊断超声在 sonothrombolysis 过程中实时监测血流和凝块力学。在本研究中，将介绍该模型，并展示使用诊断和高强度聚焦超声的初步可行性结果。
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