Bader Kenneth B, Bouchoux Guillaume, Holland Christy K
Division of Cardiovascular Health and Disease, Department of Internal Medicine, College of Medicine, University of Cincinnati, Cincinnati, OH, USA.
Adv Exp Med Biol. 2016;880:339-62. doi: 10.1007/978-3-319-22536-4_19.
Thrombo-occlusive disease is a leading cause of morbidity and mortality. In this chapter, the use of ultrasound to accelerate clot breakdown alone or in combination with thrombolytic drugs will be reported. Primary thrombus formation during cardiovascular disease and standard treatment methods will be discussed. Mechanisms for ultrasound enhancement of thrombolysis, including thermal heating, radiation force, and cavitation, will be reviewed. Finally, in-vitro, in-vivo and clinical evidence of enhanced thrombolytic efficacy with ultrasound will be presented and discussed.
血栓闭塞性疾病是发病和死亡的主要原因。在本章中，将报告单独使用超声或与溶栓药物联合使用以加速血栓溶解的情况。还将讨论心血管疾病期间的原发性血栓形成及标准治疗方法。将回顾超声增强溶栓的机制，包括热加热、辐射力和空化作用。最后，将展示并讨论超声增强溶栓疗效的体外、体内及临床证据。
