Fass R J
Antimicrob Agents Chemother. 1983 Oct;24(4):568-74. doi: 10.1128/AAC.24.4.568.
The in vitro activities of ciprofloxacin (Bay o 9867) and seven comparative antimicrobial agents against 664 aerobic and facultatively anaerobic bacterial isolates were studied. Minimal inhibitory concentrations (MICs) of ciprofloxacin were less than or equal to 2 micrograms/ml for Enterobacteriaceae, less than or equal to 8 micrograms/ml for nonfermentative gram-negative bacilli, less than or equal to 4 micrograms/ml for gram-positive cocci, less than or equal to 0.03 micrograms/ml for Aeromonas hydrophila and Pasteurella multocida, and less than or equal to 1 microgram/ml for Listeria monocytogenes. MICs for multi-drug-resistant Enterobacteriaceae and Pseudomonas aeruginosa were less than or equal to 4 micrograms/ml. Ciprofloxacin MICs were consistently 0 to 4 (usually 2 to 3) dilution steps lower than those of a related drug, norfloxacin (P less than 0.0001). For most species, they were lower than MICs of cefotaxime, aztreonam, theinamycin, mezlocillin, trimethoprim-sulfamethoxazole, and amikacin. With all eight drugs, increasing the inoculum size by 100-fold had a variable effect on MICs which was species related. Ciprofloxacin is a potent broad-spectrum new antimicrobial agent.
研究了环丙沙星（拜奥9867）和七种对照抗菌药物对664株需氧及兼性厌氧细菌分离株的体外活性。环丙沙星对肠杆菌科细菌的最低抑菌浓度（MIC）小于或等于2微克/毫升，对非发酵革兰氏阴性杆菌小于或等于8微克/毫升，对革兰氏阳性球菌小于或等于4微克/毫升，对嗜水气单胞菌和多杀巴斯德菌小于或等于0.03微克/毫升，对单核细胞增生李斯特菌小于或等于1微克/毫升。耐多药肠杆菌科细菌和铜绿假单胞菌的MIC小于或等于4微克/毫升。环丙沙星的MIC始终比相关药物诺氟沙星低0至4（通常为2至3）个稀释度（P<0.0001）。对于大多数菌种，其MIC低于头孢噻肟、氨曲南、硫霉素、美洛西林、甲氧苄啶-磺胺甲恶唑和阿米卡星的MIC。使用所有八种药物时，接种量增加100倍对MIC有不同影响，这与菌种有关。环丙沙星是一种强效的广谱新型抗菌药物。
