Galetto D W, Boscia J A, Kobasa W D, Kaye D
J Infect Dis. 1986 Jul;154(1):69-75. doi: 10.1093/infdis/154.1.69.
This study compared teicoplanin with vancomycin without and with gentamicin and/or rifampin for treatment of experimental endocarditis due to methicillin-resistant Staphylococcus epidermidis. In rabbits treated for three days and killed 12 hr after the last doses of antimicrobial agents, no significant difference in reducing bacterial titers of vegetations was detected between vancomycin and teicoplanin without and with gentamicin and/or rifampin. Addition of gentamicin and/or rifampin to vancomycin or teicoplanin significantly reduced bacterial titers of vegetations compared with vancomycin or teicoplanin alone. Addition of rifampin alone or gentamicin plus rifampin was significantly more effective than addition of gentamicin alone. In rabbits treated for three days and killed seven days after the last doses of antimicrobial agents, no significant difference in sterilizing vegetations was detected between vancomycin and teicoplanin with gentamicin and/or rifampin. However, there was a trend (probably due to the longer elimination half-life of teicoplanin in serum) that clearly favored teicoplanin over vancomycin. Teicoplanin plus rifampin without or with gentamicin is at least as effective as vancomycin plus rifampin without or with gentamicin for treatment of experimental endocarditis due to methicillin-resistant S. epidermidis.
本研究比较了替考拉宁与万古霉素（分别联合或不联合庆大霉素和/或利福平）治疗耐甲氧西林表皮葡萄球菌所致实验性心内膜炎的效果。在接受三天治疗并于最后一剂抗菌药物给药12小时后处死的兔子中，万古霉素与替考拉宁（无论是否联合庆大霉素和/或利福平）在降低赘生物细菌滴度方面未检测到显著差异。与单独使用万古霉素或替考拉宁相比，在万古霉素或替考拉宁中添加庆大霉素和/或利福平可显著降低赘生物的细菌滴度。单独添加利福平或庆大霉素加rifampin比单独添加庆大霉素显著更有效。在接受三天治疗并于最后一剂抗菌药物给药七天后处死的兔子中，万古霉素与联合庆大霉素和/或利福平的替考拉宁在使赘生物灭菌方面未检测到显著差异。然而，存在一种趋势（可能是由于替考拉宁在血清中的消除半衰期较长），明显有利于替考拉宁而非万古霉素。对于耐甲氧西林表皮葡萄球菌所致实验性心内膜炎的治疗，含或不含庆大霉素的替考拉宁加rifampin至少与含或不含庆大霉素的万古霉素加rifampin一样有效。
