Department of Hygiene, Microbiology and Social Medicine, Division of Hygiene and Medical Microbiology, Medical University Innsbruck, Innsbruck, Tirol, Austria.
Curr Pharm Des. 2013;19(20):3679-88. doi: 10.2174/13816128113199990366.
Disease manifestations with Aspergillus spp. are very diverse and dependent on interaction between the fungus and the host. Invasive aspergillosis (IA) is the most severe form of Aspergillus - associated disease found in immunocompromised hosts. Infections are mainly due to Aspergillus (A.) fumigatus, an air-borne opportunistic pathogen that causes 90% of IA. Mortality rate of this disease is still very high (50-95%), partly because of diagnostic difficulties, limited antifungal treatment options, weak conditions of patients at risk; but also in part because understanding of virulence factors involved in A. fumigatus pathogenicity and interactions of the pathogen with the host immune system is still poor. This review focuses on properties of A. fumigatus in terms of putative virulence factors and interactions of the pathogen with a main focus on the innate immune system.
疾病表现与曲霉菌属非常多样化，取决于真菌与宿主之间的相互作用。侵袭性曲霉病（IA）是免疫功能低下宿主中最严重的曲霉相关疾病。感染主要由曲霉菌（A.）烟曲霉引起，烟曲霉是一种空气传播的机会性病原体，可引起 90%的 IA。这种疾病的死亡率仍然很高（50-95%），部分原因是诊断困难、抗真菌治疗选择有限、患者病情虚弱；但部分原因还在于对烟曲霉致病性和病原体与宿主免疫系统相互作用中涉及的毒力因子的理解仍然有限。这篇综述重点介绍了烟曲霉在潜在毒力因子方面的特性，以及病原体与固有免疫系统的相互作用。
