Centro Nacional de Investigaciones Cardiovasculares, Madrid, Spain.
Immunol Rev. 2013 Jan;251(1):125-42. doi: 10.1111/imr.12013.
The transfer of molecules between cells during cognate immune cell interactions has been reported, and recently a novel mechanism of transfer of proteins and genetic material such as small RNA between T cells and antigen-presenting cells (APCs) has been described, involving exchange of extracellular vesicles (EVs) during the formation of the immunological synapse (IS). EVs, a term that encompasses exosomes and microvesicles, has been implicated in cell-cell communication during immune responses associated with tumors, pathogens, allergies, and autoimmune diseases. This review focuses on EV transfer as a mechanism for the exchange of molecules during immune cell-cell interactions.
细胞间在同源免疫细胞相互作用过程中分子的转移已有报道，最近还描述了一种新的蛋白质和遗传物质（如小 RNA）在 T 细胞和抗原呈递细胞（APCs）之间转移的机制，该机制涉及在免疫突触（IS）形成过程中外泌体（EVs）的交换。EVs 是一个包含外泌体和微泡的术语，它与与肿瘤、病原体、过敏和自身免疫性疾病相关的免疫反应中的细胞间通讯有关。这篇综述重点介绍了 EV 转移作为免疫细胞-细胞相互作用过程中分子交换的一种机制。
