Olds L C, Miller J J
Children's Hospital, Stanford, California 94304.
Arthritis Rheum. 1990 Apr;33(4):520-4. doi: 10.1002/art.1780330409.
IgM antibodies to monophosphoryl-lipid A were found to be elevated in sera from children with all forms of juvenile arthritis (JA) and systemic lupus erythematosus. Of more interest, in patients with pauciarticular JA, IgG antibody titers to monophosphoryl-lipid A were found to be correlated with the C3a concentration and the C3d:C3 ratio. Although the full specificity of these antibodies is unknown, they are the first that have been found to be correlated with complement activation products in any form of JA.
在患有各种形式幼年特发性关节炎（JA）和系统性红斑狼疮的儿童血清中，发现抗单磷酰脂质A的IgM抗体升高。更有意思的是，在少关节型JA患者中，发现抗单磷酰脂质A的IgG抗体滴度与C3a浓度以及C3d:C3比值相关。尽管这些抗体的完全特异性尚不清楚，但它们是首次被发现与任何形式JA中的补体激活产物相关的抗体。
