Olds L C, Miller J J
Children's Hospital, Stanford University School of Medicine, California.
Acta Univ Carol Med (Praha). 1991;37(1-2):37-40.
The titer of IgG and IgM antibodies to two fragments of endotoxin derived from Salmonella minnesota R 595, lipid A width a 2-keto-3-deoxyoctanate oliosaccharide (KDO lipid A), and monophosphoryl lipid A (mono-P lipid), were measured in normal children, children with cystic fibrosis, and children with SLE and all forms of chronic juvenile arthritis. Elevated titers of IgM anti mono-P lipid A were found in all of the rheumatic diseases, but not in cystic fibrosis. The elevated IgM titers were not correlated with concentration of activation fragments of C3 or C4, but IgG anti mono-P lipid A titers, even though not usually elevated, did correlate with C3a and C3d concentrations. The elevated IgM titers to mono-P lipid A may represent a genetically determined hyper-reactivity to normal gastrointestinal antigens, an increased antigenic stimulus from the intestinal tract, or polyspecificity of an antibody of undetermined primary reactivity.
在正常儿童、囊性纤维化患儿、系统性红斑狼疮患儿以及所有类型的慢性幼年型关节炎患儿中，检测了针对源自明尼苏达沙门氏菌R 595的两种内毒素片段（脂多糖A、含2-酮-3-脱氧辛酸寡糖的脂多糖A（KDO脂多糖A）和单磷酰脂多糖A（单磷脂A））的IgG和IgM抗体滴度。在所有风湿性疾病患儿中均发现抗单磷脂A的IgM滴度升高，而囊性纤维化患儿中未出现。升高的IgM滴度与C3或C4激活片段的浓度无关，但抗单磷脂A的IgG滴度虽然通常未升高，但确实与C3a和C3d浓度相关。抗单磷脂A的IgM滴度升高可能代表对正常胃肠道抗原的遗传决定的高反应性、来自肠道的抗原刺激增加，或具有未确定主要反应性的抗体的多特异性。
