Institute for Medicine and Neurosciences, Research Center Jülich, Jülich, Germany.
Ann Neurol. 2012 Nov;72(5):816-20. doi: 10.1002/ana.23663.
Coordinated reset neuromodulation consists of the application of consecutive brief high-frequency pulse trains through the different contacts of the stimulation electrode. In theoretical studies, by achieving unlearning of abnormal connectivity between neurons, coordinated reset neuromodulation reduces pathological synchronization, a hallmark feature of Parkinson's disease pathophysiology. Here we show that coordinated reset neuromodulation of the subthalamic nucleus has both acute and sustained long-lasting aftereffects on motor function in parkinsonian nonhuman primates. Long-lasting aftereffects were not observed with classical deep brain stimulation. These observations encourage further development of coordinated reset neuromodulation for treating motor symptoms in Parkinson disease patients.
协调重设神经调节包括通过刺激电极的不同触点施加连续短暂的高频脉冲串。在理论研究中，通过实现神经元之间异常连接的去学习，协调重设神经调节减少了病理同步，这是帕金森病病理生理学的一个标志特征。在这里，我们表明，丘脑底核的协调重设神经调节对帕金森病非人类灵长类动物的运动功能既有急性的又有持续的持久的后效。经典的深部脑刺激则没有观察到持久的后效。这些观察结果鼓励进一步开发协调重设神经调节，以治疗帕金森病患者的运动症状。
