Department of Pharmacognosy, Faculty of Pharmacy, University of Belgrade, V. Stepe 450, 11221, Belgrade, Serbia.
Phytother Res. 2013 Nov;27(11):1658-63. doi: 10.1002/ptr.4919. Epub 2012 Dec 27.
In this study, we investigated the antimicrobial activity of the young shoots of the smoke tree, Cotinus coggygria Scop., Anacardiaceae. The acetone extract and the derived ethyl acetate fraction effectively inhibited the growth of Gram-positive and Gram-negative bacteria (MIC 25-200 µg/ml), while the chloroform fraction showed pronounced activity against the yeast Candida albicans (MIC 3.12 µg/ml). The ethyl acetate fraction exhibited a significant ferric-reducing ability (10.7 mmol Fe(2+) /g extract), a very high DPPH radical scavenging activity (SC50 = 1.7 µg/ml) and inhibition of lipid peroxidation (IC50 = 41.8 µg/ml). High amounts of total phenolics (929.8 mg/g), tannins (833.8 mg/g) and flavonoids (35.5 mg/g) were determined in the ethyl acetate fraction, which also exerted significant anti-inflammatory (76.7%) and cytotoxic effects (IC50 = 15.6 µg/ml).
在这项研究中，我们研究了烟树（Cotinus coggygria Scop.）幼枝的抗菌活性，漆树科。丙酮提取物和衍生的乙酸乙酯部分有效地抑制革兰氏阳性和革兰氏阴性细菌的生长（MIC 25-200μg/ml），而氯仿部分对白色念珠菌（Candida albicans）表现出显著的活性（MIC 3.12μg/ml）。乙酸乙酯部分表现出很强的铁还原能力（10.7mmol Fe(2+)/g 提取物），很高的 DPPH 自由基清除活性（SC50=1.7μg/ml）和抑制脂质过氧化（IC50=41.8μg/ml）。在乙酸乙酯部分中测定了大量的总酚（929.8mg/g）、单宁（833.8mg/g）和类黄酮（35.5mg/g），该部分还表现出显著的抗炎（76.7%）和细胞毒性作用（IC50=15.6μg/ml）。
