造血干细胞龛——朋友与敌人的家园？
The hematopoietic stem cell niche--home for friend and foe?
机构信息
Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
出版信息
Cytometry B Clin Cytom. 2013 Jan-Feb;84(1):7-20. doi: 10.1002/cyto.b.21066. Epub 2012 Dec 26.
Abstract
The hematopoietic stem cell (HSC) niche is involved in the maintainance and regulation of quiescence, self-renewal and differentiation of hematopoietic stem cells and the fate of their progeny in mammals dealing with the daily stresses to the hematopoietic system. From the discovery that perturbations of the HSC niche can lead to hematopoietic disorders, we have now arrived at the prospect that the HSC niche may play a role in hematological malignancies and that this HSC niche may be a target for therapy. This review attempts to capture the discoveries of the last few years regarding the normal and malignant hematopoietic stem cell niche and possible ways to target this niche.
摘要
造血干细胞 (HSC) 龛参与维持和调节哺乳动物造血干细胞的静止、自我更新和分化，以及其后代的命运，以应对造血系统的日常压力。从发现 HSC 龛的扰动会导致造血障碍，到现在我们已经认识到 HSC 龛可能在血液恶性肿瘤中发挥作用，并且这个 HSC 龛可能是治疗的靶点。这篇综述试图总结过去几年关于正常和恶性造血干细胞龛的发现，以及靶向这个龛的可能方法。
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