Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, TX 75309-9069, USA.
Photodermatol Photoimmunol Photomed. 2013 Feb;29(1):4-11. doi: 10.1111/phpp.12018.
Ultraviolet radiation (UVR) is a well-known exacerbating factor for cutaneous lupus erythematosus (CLE), with photosensitivity comprising one of the American College of Rheumatology (ACR) diagnostic criteria for systemic lupus erythematosus (SLE). However, discerning true photosensitivity in this population is difficult due to the broad language utilized by the ACR and the delayed-onset nature of photosensitive lupus lesions.
The objective of this report is to provide a review of photosensitivity, photoprovocation, and phototherapy in the context of CLE patients.
A literature review in PubMed was conducted using the terms 'ultraviolet light,' 'lupus erythematosus,' 'photoprovocation,' or 'photosensitivity.'
Self-patient reporting of photosensitivity and the broad definition of photosensitivity have led to the wide range of photosensitivity rates in CLE patients. Photoprovocation testing provides a more objective method to measure photosensitivity, but even these trials demonstrate significant differences due to protocol variations. Despite UVR's deleterious effect on lupus patients, ultraviolet A (UVA)-1 may have therapeutic benefits as shown by observations on murine models and human lupus subjects.
Accurately discerning photosensitivity has diagnostic implications for SLE and provides motivation for greater patient adherence to photoprotective methods.
紫外线（UVR）是一种众所周知的皮肤狼疮性红斑（CLE）恶化因素，光敏感是美国风湿病学会（ACR）全身性红斑狼疮（SLE）诊断标准之一。然而，由于 ACR 广泛使用的语言以及光敏感狼疮病变的迟发性，在该人群中辨别真正的光敏感是困难的。
本报告的目的是在 CLE 患者的背景下综述光敏感、光激发和光疗。
在 PubMed 上使用术语“紫外线”、“红斑狼疮”、“光激发”或“光敏感”进行文献复习。
患者自我报告的光敏感和光敏感的广泛定义导致了 CLE 患者光敏感率的广泛差异。光激发试验提供了一种更客观的测量光敏感的方法，但即使是这些试验也由于方案的差异而显示出显著的差异。尽管 UVR 对狼疮患者有有害影响，但紫外线 A（UVA）-1 可能具有治疗益处，这已在鼠模型和人类狼疮患者的观察中得到证实。
准确辨别光敏感对 SLE 具有诊断意义，并为患者更好地遵守光保护方法提供了动力。
