工作压力与血脂异常的关系。

The relationship between job stress and dyslipidemia.

机构信息

Ibermutuamur (Mutua de Accidentes de Trabajo y Enfermedades Profesionales de la Seguridad Social 274), Madrid, Spain.

出版信息

Scand J Public Health. 2013 Mar;41(2):142-9. doi: 10.1177/1403494812470400. Epub 2013 Jan 2.

DOI:10.1177/1403494812470400

PMID:23282939

Abstract

AIMS

To investigate whether there is an association between job stress, lipid profile and dyslipidemia diagnosis.

METHODS

This study used a questionnaire to evaluate job stress and lifestyle variables in 91,593 workers undergoing periodic checkups. Serum lipid levels were measured in all cases.

RESULTS

The prevalence of job stress was 8.7% (95% CI, 8.5-8.8%). In bivariate analyses, job stress was significantly associated with previous dyslipidemia diagnosis (p < 0.001), lipid-lowering therapy (p < 0.001), and altered total-cholesterol (p = 0.001), HDL-cholesterol (p < 0.001) and LDL-cholesterol levels (p = 0.025). After adjusting for potential confounding variables, job stress was still associated with current dyslipidemia diagnosis (OR = 1.10; 95% CI, 1.04-1.17), high LDL-cholesterol (OR = 1.14; 95% CI, 1.05-1.23), low HDL-cholesterol (OR 1.08; 95% CI, 1.01-1.15), high total cholesterol/HDL-cholesterol ratio (OR 1.13; 95% CI, 1.05-1.23) and high LDL-cholesterol/HDL-cholesterol ratio (OR 1.11; 95% CI, 1.04-1.19).

CONCLUSION

These results support the hypothesis of an association between job stress and lipid disturbances.

摘要

目的

探讨工作压力与血脂异常诊断之间是否存在关联。

方法

本研究采用问卷评估了 91593 名接受定期体检的工人的工作压力和生活方式变量。所有病例均测量血清脂质水平。

结果

工作压力的患病率为 8.7%（95%CI，8.5-8.8%）。在单变量分析中，工作压力与既往血脂异常诊断（p<0.001）、降脂治疗（p<0.001）以及总胆固醇（p=0.001）、高密度脂蛋白胆固醇（p<0.001）和低密度脂蛋白胆固醇水平（p=0.025）的改变显著相关。在调整了潜在的混杂变量后，工作压力与当前血脂异常诊断（OR=1.10；95%CI，1.04-1.17）、高 LDL 胆固醇（OR=1.14；95%CI，1.05-1.23）、低 HDL 胆固醇（OR=1.08；95%CI，1.01-1.15）、高总胆固醇/HDL 胆固醇比值（OR=1.13；95%CI，1.05-1.23）和高 LDL 胆固醇/HDL 胆固醇比值（OR=1.11；95%CI，1.04-1.19）仍相关。