Division of General and Transplant Surgery, University of Pisa, Pisa, Italy.
Curr Opin Organ Transplant. 2013 Feb;18(1):102-10. doi: 10.1097/MOT.0b013e32835c28c5.
Successful pancreas transplantation restores physiologic glycemic and metabolic control. Its effects on overall patient survival (especially for simultaneous pancreas-kidney transplantation) are clear-cut. We herein review the available literature to define the impact of pancreas transplantation on chronic complications of diabetes mellitus.
With longer-term follow-up, wider patient populations, and more accurate investigational tools (clinical and functional tests, noninvasive imaging, histology, and molecular biology), growing data show that successful pancreas transplantation may slow the progression, stabilize, and even favor the regression of secondary complications of diabetes, both microvascular and macrovascular, in a relevant proportion of recipients.
Patients who are referred for pancreas transplantation usually suffer from advanced chronic complications of diabetes, which have classically been deemed irreversible. A successful pancreas transplantation is often able to slow the progression, stabilize, and even reverse many microvascular and macrovascular complications of diabetes. Growing clinical evidence shows that the expected natural history of long-term diabetic complications can be significantly modified by successful pancreas transplantation.
成功的胰腺移植恢复了生理血糖和代谢控制。它对整体患者生存的影响（特别是同时进行胰腺-肾移植）是明确的。本文综述了现有文献，以确定胰腺移植对糖尿病慢性并发症的影响。
随着长期随访、更广泛的患者群体和更准确的研究工具（临床和功能测试、非侵入性成像、组织学和分子生物学）的应用，越来越多的数据表明，成功的胰腺移植可能会减缓、稳定甚至有利于接受者的继发糖尿病并发症（微血管和大血管）的进展，在一定比例的接受者中。
被推荐进行胰腺移植的患者通常患有晚期慢性糖尿病并发症，这些并发症通常被认为是不可逆转的。成功的胰腺移植通常能够减缓进展、稳定甚至逆转许多糖尿病的微血管和大血管并发症。越来越多的临床证据表明，成功的胰腺移植可以显著改变长期糖尿病并发症的预期自然病程。
