Division of Transplantation, Department of Surgery, University of Minnesota, Minneapolis, Minnesota, USA.
Curr Opin Organ Transplant. 2014 Feb;19(1):73-9. doi: 10.1097/MOT.0000000000000045.
Recipients of pancreas transplantation bear the burden of chronic complications of diabetes, both microvascular and macrovascular. Pancreas transplantation provides the most effective method of glycemic and metabolic control. As transplantation provides immediate relief from acute complications of diabetes, the impact of a successful transplant on long-term complications is the focus of this review.
It is increasingly recognized that a successful pancreas transplant may slow, stabilize, or ameliorate the progression of macrovascular and microvascular complications of diabetes. New understanding of the genetic and epigenetic mechanisms and pathophysiology of diabetic complications has provided new data potentially useful for prospectively studying the effect of pancreas transplant on chronic complications of diabetes.
Earlier correction of diabetes by pancreas transplantation decreases chronic complications. Refinements in the understanding of the tissue targets of diabetes complications and new diagnostic and imaging tools to measure them may prove useful in further studying the impact of pancreas transplantation on chronic complications of diabetes.
胰腺移植受者承受糖尿病微血管和大血管慢性并发症的负担。胰腺移植是血糖和代谢控制最有效的方法。由于移植立即缓解糖尿病的急性并发症，成功的移植对长期并发症的影响是本综述的重点。
越来越多的人认识到，成功的胰腺移植可能会减缓、稳定或改善糖尿病大血管和微血管并发症的进展。对糖尿病并发症的遗传和表观遗传机制及病理生理学的新认识提供了新的数据，这些数据可能有助于前瞻性研究胰腺移植对糖尿病慢性并发症的影响。
胰腺移植越早纠正糖尿病，慢性并发症越少。对糖尿病并发症的组织靶点的理解的改进和新的诊断和成像工具来测量它们可能有助于进一步研究胰腺移植对糖尿病慢性并发症的影响。
