toll 样受体信号转导
Toll-like receptor signaling.
机构信息
Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
出版信息
Cold Spring Harb Perspect Biol. 2013 Jan 1;5(1):a011247. doi: 10.1101/cshperspect.a011247.
Abstract
Toll-like receptors sense pathogen-associated molecular patterns (e.g., lipopolysaccharides) and trigger gene-expression changes that ultimately eradicate the invading microbes.
摘要
Toll 样受体能够识别病原体相关分子模式（例如，脂多糖），并触发基因表达的变化，最终消灭入侵的微生物。
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1
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2
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Cold Spring Harb Perspect Biol. 2012 Mar 1;4(3):a006049. doi: 10.1101/cshperspect.a006049.
3
Expanding TRAF function: TRAF3 as a tri-faced immune regulator.拓展 TRAF 功能：TRAF3 作为一个三面向的免疫调控因子。
Nat Rev Immunol. 2011 Jun 10;11(7):457-68. doi: 10.1038/nri2998.
4
Toll-like receptor driven B cell activation in the induction of systemic autoimmunity. Toll 样受体驱动的 B 细胞激活在系统性自身免疫中的诱导作用。
Semin Immunol. 2011 Apr;23(2):106-12. doi: 10.1016/j.smim.2011.01.016.
5
Human TLRs and IL-1Rs in host defense: natural insights from evolutionary, epidemiological, and clinical genetics.人类 TLRs 和 IL-1Rs 在宿主防御中的作用：来自进化、流行病学和临床遗传学的自然见解。
Annu Rev Immunol. 2011;29:447-91. doi: 10.1146/annurev-immunol-030409-101335.
6
Oncogenically active MYD88 mutations in human lymphoma.人类淋巴瘤中致癌性激活的 MYD88 突变。
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