Xu Guan, Dar Irfaan A, Tao Chao, Liu Xiaojun, Deng Cheri X, Wang Xueding
Department of Radiology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.
Appl Phys Lett. 2012 Nov 26;101(22):221102. doi: 10.1063/1.4768703.
This study investigates the feasibility of characterizing the microstructures within a biological tissue by analyzing the frequency spectrum of the photoacoustic signal from the tissue. Hypotheses are derived from theoretical analyses on the relationships between the dimensions/concentrations of the photoacoustic sources within the region-of-interest and the linear model fitted to the power spectra of photoacoustic signals. The hypotheses are validated, following the procedures of ultrasound spectrum analysis, by simulations and experiments with phantoms fabricated by embedding the polyethylene microspheres in porcine gelatin, indicating that photoacoustic spectrum analysis could be a potential tool for characterizing microstructures in biological samples.
本研究通过分析来自生物组织的光声信号的频谱，探讨表征生物组织内部微观结构的可行性。假设源自对感兴趣区域内光声源的尺寸/浓度与拟合光声信号功率谱的线性模型之间关系的理论分析。按照超声频谱分析的程序，通过将聚乙烯微球嵌入猪明胶制成的仿体进行模拟和实验，对这些假设进行了验证，结果表明光声频谱分析可能是表征生物样品微观结构的一种潜在工具。
