Petto Jefferson, de Jesus Jaqueline Brito, Vasques Leila Monique Reis, Pinheiro Renata Leão Silva, Oliveira Aila Mascarenhas, Spinola Kelly Aparecida Borges, Silva Wellington Dos Santos
Universidade do Estado da Bahia - UNEB, Salvador (BA), Brazil ; Universidade Social da Bahia - FSBA, Salvador (BA), Brazil.
Rev Bras Hematol Hemoter. 2011;33(1):26-30. doi: 10.5581/1516-8484.20110010.
The most common hereditary hemoglobin disorder, affecting 20 million individuals worldwide, is sickle cell disease. The vascular obstruction resulting from the sickling of cells in this disease can produce local hypoxemia, pain crises and infarction in several tissues, including the bones, spleen, kidneys and lungs.
To determine red blood group genes in a Brazilian populations.
The present study is characterized as a case control study, with the aim of identifying the baseline blood lactate concentration in individuals with hemoglobin SS and SC diseases. One-way ANOVA with the Tukey post-test was used to analyze the results and a p-value < 0.05 was considered significant. Calculations were made using the INSTAT statistical program. The graphs were generated using the ORING program. The study sample was composed of 31 men and women residing in the city of Santo Antônio de Jesus, Bahia, Brazil. The individuals were divided into two groups: Group GC of 16 subjects who did not present with any type of structural hemoglobinopathy; and Group GE composed of 15 individuals with ages between 2 and 35 years old, who had the SS and SC genotypes. Sample analyses were performed with 3 mL of blood during fasting.
The baseline blood lactate concentration of the SS and SC individuals was higher than that of the control group (p<0.001) with means of 4.86 ± 0.95; 3.30 ± 0.33; 1.31 ± 0.08 IU/L for SS, SC and controls, respectively. This corroborates the initial research hypothesis.
The baseline blood lactate of SS and SC individuals is 3 to 4 times higher than that of healthy subjects, probably due to the fact that these patients have a metabolic deviation to the anaerobic pathway.
镰状细胞病是最常见的遗传性血红蛋白疾病，全球有2000万人受其影响。该疾病中细胞镰变导致的血管阻塞可在包括骨骼、脾脏、肾脏和肺部在内的多个组织中产生局部低氧血症、疼痛危象和梗死。
确定巴西人群中的红细胞血型基因。
本研究为病例对照研究，旨在确定血红蛋白SS和SC疾病患者的基础血乳酸浓度。采用单因素方差分析和Tukey事后检验分析结果，p值<0.05被认为具有统计学意义。使用INSTAT统计程序进行计算。使用ORING程序生成图表。研究样本由居住在巴西巴伊亚州圣安东尼奥 - 德热苏斯市的31名男性和女性组成。这些个体分为两组：GC组有16名未出现任何类型结构血红蛋白病的受试者；GE组由15名年龄在2至35岁之间、具有SS和SC基因型的个体组成。空腹时采集3 mL血液进行样本分析。
SS和SC个体的基础血乳酸浓度高于对照组（p<0.001），SS、SC和对照组的均值分别为4.86±0.95、3.30±0.33、1.31±0.08 IU/L。这证实了最初的研究假设。
SS和SC个体的基础血乳酸比健康受试者高3至4倍，可能是因为这些患者存在向无氧代谢途径的代谢偏差。
