Melo Hugo Nivaldo, Stoots Simone Joanna-Maria, Pool Marijn Aimee, Carvalho Vitor Oliveira, Almeida Lucas Oliveira Carvalho, Aragão Max Luan De Carvalho, Agyemang Charles, Cipolotti Rosana
Universidade Federal de Sergipe (UFS), Aracaju, SE, Brazil.
University of Amsterdam (UvA), Amsterdam, Netherlands.
Rev Bras Hematol Hemoter. 2017 Apr-Jun;39(2):133-139. doi: 10.1016/j.bjhh.2017.02.009. Epub 2017 Mar 31.
To establish determinants of maximum walking distance in the 6-minute walk test of children and adolescents with sickle cell anemia, and to compare the performance in this test with physical activity level between patients and healthy controls.
A cross-sectional study was performed in which the participants answered the Physical Activity Questionnaire for Older Children and Adolescents, and completed the 6-minute walk test.
Fifty-seven patients and 58 controls were studied. By univariate analysis of the patients, age (p<0.0001) and indirect bilirubin (p=0.008) were associated with maximum walking distance in the 6-minute walk test. In multivariate analysis, age was positively associated (p<0.0001; beta: 0.75), while body mass index was inversely associated with distance walked (p=0.047; beta: -0.32). This yields the following equation: maximum distance walked=487.7 (age×18.3)-(12×body mass index) meters. Patients reported a lower physical activity level however there was no significant difference in the distance walked in six minutes between patients (500.6±88.7m) and controls (536.3±94m).
The determinants for the 6-minute walk test in children and adolescents with sickle cell anemia were age and body mass index. There was no significant difference in the 6-minute walk test but patients with sickle cell anemia had a lower physical activity level compared to healthy controls.
确定镰状细胞贫血儿童和青少年6分钟步行试验中最大步行距离的决定因素，并比较患者与健康对照在该试验中的表现与身体活动水平。
进行了一项横断面研究，参与者回答了《大龄儿童和青少年身体活动问卷》，并完成了6分钟步行试验。
研究了57名患者和58名对照。对患者进行单因素分析，年龄（p<0.0001）和间接胆红素（p=0.008）与6分钟步行试验中的最大步行距离相关。多因素分析中，年龄呈正相关（p<0.0001；β：0.75），而体重指数与步行距离呈负相关（p=0.047；β：-0.32）。由此得出以下方程：最大步行距离=487.7（年龄×18.3）-（12×体重指数）米。患者报告的身体活动水平较低，然而患者（500.6±88.7米）和对照（536.3±94米）在6分钟内步行的距离没有显著差异。
镰状细胞贫血儿童和青少年6分钟步行试验的决定因素是年龄和体重指数。6分钟步行试验中没有显著差异，但与健康对照相比，镰状细胞贫血患者的身体活动水平较低。
