• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

镰状细胞病视网膜病变：巴西东北部儿童和青少年患者的特征

Sickle cell disease retinopathy: characterization among pediatric and teenage patients from northeastern Brazil.

作者信息

de Almeida Oliveira Dayse Cury, Carvalho Magda O S, do Nascimento Valma Maria Lopes, Villas-Bôas Flávia Silva, Galvão-Castro Bernardo, Goncalves Marilda Souza

机构信息

Instituto Brasileiro de Oftalmologia e Prevenção da Cegueira (IBOPC), Salvador, BA, Brazil; Escola Bahiana de Medicina e Saúde Publica (EBMSP), Salvador, BA, Brazil.

Universidade Federal da Bahia (UFBA), Salvador, BA, Brazil; Centro de Pesquisa Gonçalo Moniz - Fundação Oswaldo Cruz - (CPqGM-FIOCRUZ), Salvador, BA, Brazil.

出版信息

Rev Bras Hematol Hemoter. 2014 Sep-Oct;36(5):340-4. doi: 10.1016/j.bjhh.2014.07.012. Epub 2014 Jul 18.

DOI:10.1016/j.bjhh.2014.07.012
PMID:25305166
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4318384/
Abstract

OBJECTIVE

The aim of the present study was to characterize sickle cell disease retinopathy in children and teenagers from Bahia, the state in northeastern Brazil with the highest incidence and prevalence of sickle cell disease.

METHODS

A group of 51 sickle cell disease patients (36 hemoglobin SS and 15 hemoglobin SC) with ages ranging from 4 to 18 years was studied. Ophthalmological examinations were performed in all patients. Moreover, a fluorescein angiography was also performed in over 10-year-old patients.

RESULTS

The most common ocular lesions were vascular tortuosity, which was found in nine (25%) hemoglobin SS patients, and black sunburst, in three (20%) hemoglobin SC patients. Peripheral arterial closure was observed in five (13.9%) hemoglobin SS patients and in three (13.3%) hemoglobin SC patients. Arteriovenous anastomoses were present in six (16.5%) hemoglobin SS patients and six (37.5%) hemoglobin SC patients. Neovascularization was not identified in any of the patients.

CONCLUSIONS

This study supports the use of early ophthalmological examinations in young sickle cell disease patients to prevent the progression of retinopathy to severe disease and further blindness.

摘要

目的

本研究旨在对来自巴西东北部巴伊亚州的儿童和青少年镰状细胞病视网膜病变进行特征描述，该州是镰状细胞病发病率和患病率最高的州。

方法

对一组年龄在4至18岁之间的51例镰状细胞病患者（36例血红蛋白SS型和15例血红蛋白SC型）进行了研究。对所有患者进行了眼科检查。此外，还对10岁以上的患者进行了荧光素血管造影。

结果

最常见的眼部病变是血管迂曲，在9例（25%）血红蛋白SS型患者中发现，以及黑色太阳状斑，在3例（20%）血红蛋白SC型患者中发现。在5例（13.9%）血红蛋白SS型患者和3例（13.3%）血红蛋白SC型患者中观察到周边动脉闭塞。动静脉吻合在6例（16.5%）血红蛋白SS型患者和6例（37.5%）血红蛋白SC型患者中存在。在任何患者中均未发现新生血管形成。

结论

本研究支持对年轻镰状细胞病患者进行早期眼科检查，以防止视网膜病变进展为严重疾病并进一步导致失明。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e4c/4318384/548f20dc3e2e/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e4c/4318384/4e3b1c2668e6/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e4c/4318384/e21d7511c244/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e4c/4318384/ec4466958140/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e4c/4318384/548f20dc3e2e/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e4c/4318384/4e3b1c2668e6/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e4c/4318384/e21d7511c244/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e4c/4318384/ec4466958140/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e4c/4318384/548f20dc3e2e/gr4.jpg

相似文献

1
Sickle cell disease retinopathy: characterization among pediatric and teenage patients from northeastern Brazil.镰状细胞病视网膜病变：巴西东北部儿童和青少年患者的特征
Rev Bras Hematol Hemoter. 2014 Sep-Oct;36(5):340-4. doi: 10.1016/j.bjhh.2014.07.012. Epub 2014 Jul 18.
2
[Retinal impairment in young individuals with sickle cell anemia (hemoglobin SS disease) in university hospital in Northeastern of Brazil].[巴西东北部大学医院镰状细胞贫血（血红蛋白SS病）年轻患者的视网膜病变]
Arq Bras Oftalmol. 2012 Oct;75(5):313-5. doi: 10.1590/s0004-27492012000500003.
3
Sickle cell retinopathy in young children in Jamaica.牙买加幼儿的镰状细胞视网膜病变
Br J Ophthalmol. 1982 Mar;66(3):149-54. doi: 10.1136/bjo.66.3.149.
4
Relationship between peripheral vascular closure and proliferative retinopathy in sickle cell disease.镰状细胞病中外周血管闭塞与增殖性视网膜病变的关系。
Graefes Arch Clin Exp Ophthalmol. 1991;229(6):543-8. doi: 10.1007/BF00203319.
5
Incidence and natural history of proliferative sickle cell retinopathy: observations from a cohort study.增殖性镰状细胞视网膜病变的发病率及自然病程：一项队列研究的观察结果
Ophthalmology. 2005 Nov;112(11):1869-75. doi: 10.1016/j.ophtha.2005.05.026. Epub 2005 Sep 19.
6
[Sickle-cell retinopathy: Retrospective study of 730 patients followed in a referral center].镰状细胞视网膜病变：对一家转诊中心随访的730例患者的回顾性研究
J Fr Ophtalmol. 2012 May;35(5):343-7. doi: 10.1016/j.jfo.2011.10.007. Epub 2012 Apr 1.
7
A screening strategy for the detection of sickle cell retinopathy in pediatric patients.一种用于检测儿科患者镰状细胞视网膜病变的筛查策略。
Can J Ophthalmol. 2008 Apr;43(2):188-91. doi: 10.3129/i08-003.
8
Clinical and laboratory factors associated with the severity of proliferative sickle cell retinopathy in patients with sickle cell hemoglobin C (SC) and homozygous sickle cell (SS) disease.与镰状细胞血红蛋白C（SC）病和纯合子镰状细胞（SS）病患者增生性镰状细胞视网膜病变严重程度相关的临床和实验室因素。
Medicine (Baltimore). 2011 Nov;90(6):372-378. doi: 10.1097/MD.0b013e3182364cba.
9
Proliferative sickle cell retinopathy under age 20: a review.20岁以下增殖性镰状细胞视网膜病变：综述
Ophthalmic Surg. 1987 Feb;18(2):126-8.
10
Reference values and hematologic changes from birth to 5 years in patients with sickle cell disease. Cooperative Study of Sickle Cell Disease.镰状细胞病患者从出生到5岁的参考值及血液学变化。镰状细胞病合作研究。
Arch Pediatr Adolesc Med. 1994 Aug;148(8):796-804. doi: 10.1001/archpedi.1994.02170080026005.

引用本文的文献

1
Hydroxyurea treatment is associated with reduced degree of oxidative perturbation in children and adolescents with sickle cell anemia.羟基脲治疗可降低镰状细胞贫血儿童和青少年氧化应激损伤程度。
Sci Rep. 2020 Nov 4;10(1):18982. doi: 10.1038/s41598-020-76075-5.
2
Wide-field imaging of sickle retinopathy.镰状视网膜病变的广角成像。
Int J Retina Vitreous. 2019 Dec 12;5(Suppl 1):27. doi: 10.1186/s40942-019-0177-8. eCollection 2019.
3
Awareness of Ocular Manifestations, Complications, and Treatment of Sickle Cell Disease in the Eastern Province of Saudi Arabia: A Cross-Sectional Study.

本文引用的文献

1
Ocular findings in sickle cell disease patients in Lagos.拉各斯镰状细胞病患者的眼部检查结果
Niger Postgrad Med J. 2004 Sep;11(3):203-6.
2
Distribution of abnormal hemoglobins and glucose-6-phosphate dehydrogenase variants in 1200 school children of Bahia, Brazil.巴西巴伊亚州1200名学童中异常血红蛋白和葡萄糖-6-磷酸脱氢酶变体的分布情况。
Am J Phys Anthropol. 1980 Nov;53(4):509-12. doi: 10.1002/ajpa.1330530407.
3
Spread and diversity of human populations in Bahia, Brazil.巴西巴伊亚州的人口分布与多样性。
沙特阿拉伯东部省镰状细胞病眼部表现、并发症及治疗的知晓情况：一项横断面研究
Middle East Afr J Ophthalmol. 2019 Aug 26;26(2):89-94. doi: 10.4103/meajo.MEAJO_200_18. eCollection 2019 Apr-Jun.
4
Ocular manifestations of sickle cell disease and genetic susceptibility for refractive errors.镰状细胞病的眼部表现及屈光不正的遗传易感性。
Taiwan J Ophthalmol. 2017 Apr-Jun;7(2):89-93. doi: 10.4103/tjo.tjo_3_17.
5
Sickle cell retinopathy: improving care with a multidisciplinary approach.镰状细胞视网膜病变：采用多学科方法改善护理
J Multidiscip Healthc. 2017 Aug 30;10:335-346. doi: 10.2147/JMDH.S90630. eCollection 2017.
6
Optical Coherence Tomography Angiography and Ultra-widefield Fluorescein Angiography for Early Detection of Adolescent Sickle Retinopathy.光学相干断层扫描血管造影术和超广角荧光素血管造影术用于青少年镰状视网膜病变的早期检测。
Am J Ophthalmol. 2017 Nov;183:91-98. doi: 10.1016/j.ajo.2017.08.010. Epub 2017 Aug 30.
7
New Ways to Detect Pediatric Sickle Cell Retinopathy: A Comprehensive Review.检测小儿镰状细胞视网膜病变的新方法：全面综述
J Pediatr Hematol Oncol. 2017 Nov;39(8):618-625. doi: 10.1097/MPH.0000000000000919.
8
Oral Monomethyl Fumarate Therapy Ameliorates Retinopathy in a Humanized Mouse Model of Sickle Cell Disease.口服富马酸单甲酯疗法可改善镰状细胞病人类化小鼠模型中的视网膜病变。
Antioxid Redox Signal. 2016 Dec 10;25(17):921-935. doi: 10.1089/ars.2016.6638. Epub 2016 Aug 22.
9
An eye on sickle cell retinopathy.关注镰状细胞视网膜病变
Rev Bras Hematol Hemoter. 2014 Sep-Oct;36(5):319-21. doi: 10.1016/j.bjhh.2014.07.020. Epub 2014 Aug 12.
Hum Biol. 1982 May;54(2):329-41.
4
Sickle cell retinopathy in young children in Jamaica.牙买加幼儿的镰状细胞视网膜病变
Br J Ophthalmol. 1982 Mar;66(3):149-54. doi: 10.1136/bjo.66.3.149.
5
Sickle-cell hemoglobin and its relation to fundus abnormality.镰状细胞血红蛋白及其与眼底异常的关系。
Arch Ophthalmol. 1966 Mar;75(3):353-62. doi: 10.1001/archopht.1966.00970050355008.
6
Classification and pathogenesis of proliferative sickle retinopathy.增殖性镰状视网膜病变的分类与发病机制
Am J Ophthalmol. 1971 Mar;71(3):649-65. doi: 10.1016/0002-9394(71)90429-6.
7
Ocular findings in hemoglobin SC disease in Jamaica.牙买加血红蛋白SC病的眼部表现
Am J Ophthalmol. 1972 Nov;74(5):921-31. doi: 10.1016/0002-9394(72)91213-5.
8
Patterns of visual loss in untreated sickle cell retinopathy.未经治疗的镰状细胞视网膜病变的视力丧失模式。
Eye (Lond). 1988;2 ( Pt 3):330-5. doi: 10.1038/eye.1988.62.
9
Funduscopic alterations in SS and SC hemoglobinopathies. Study of a Brazilian population.镰状细胞贫血（SS）和镰状细胞特性（SC）血红蛋白病的眼底改变。对巴西人群的研究。
Ophthalmologica. 1988;197(1):26-33. doi: 10.1159/000309913.
10
The evolution of salmon-patch hemorrhages in sickle cell retinopathy.镰状细胞视网膜病变中鲑鱼斑状出血的演变
Arch Ophthalmol. 1989 Dec;107(12):1814-5. doi: 10.1001/archopht.1989.01070020896034.