Columbia University, College of Physicians and Surgeons, New York, NY, USA.
PLoS One. 2012;7(12):e52842. doi: 10.1371/journal.pone.0052842. Epub 2012 Dec 21.
Southeast Asia is a region with great potential for the emergence of a pandemic influenza virus. Global efforts to improve influenza surveillance in this region have documented the burden and seasonality of influenza viruses and have informed influenza prevention strategies, but little information exists about influenza vaccination guidelines and vaccine sales.
To ascertain the existence of influenza vaccine guidelines and define the scope of vaccine sales, we sent a standard three-page questionnaire to the ten member nations of the Association of Southeast Asian Nations. We also surveyed three multinational manufacturers who supply influenza vaccines in the region.
Vaccine sales in the private sector were <1000 per 100,000 population in the 10 countries. Five countries reported purchasing vaccine for use in the public sector. In 2011, Thailand had the highest combined reported rate of vaccine sales (10,333 per 100,000). In the 10 countries combined, the rate of private sector sales during 2010-2011 (after the A(H1N1)2009pdm pandemic) exceeded 2008 pre-pandemic levels. Five countries (Indonesia, Malaysia, Singapore, Thailand and Vietnam) had guidelines for influenza vaccination but only two were consistent with global guidelines. Four recommended vaccination for health care workers, four for elderly persons, three for young children, three for persons with underlying disease, and two for pregnant women.
The rate of vaccine sales in Southeast Asia remains low, but there was a positive impact in sales after the A(H1N1)2009pdm pandemic. Low adherence to global vaccine guidelines suggests that more work is needed in the policy arena.
东南亚是一个具有很大潜力出现大流行性流感病毒的地区。全球努力提高该地区的流感监测工作,记录了流感病毒的负担和季节性,并为流感预防策略提供了信息,但关于流感疫苗接种指南和疫苗销售的信息很少。
为了确定是否存在流感疫苗指南并确定疫苗销售范围,我们向东南亚国家联盟的十个成员国发送了一份标准的三页问卷。我们还调查了三家向该地区供应流感疫苗的跨国制造商。
在私营部门,这 10 个国家的疫苗销售量均低于每 10 万人 1000 支。有五个国家报告说购买了用于公共部门的疫苗。2011 年,泰国的疫苗销售量最高(每 10 万人 10333 支)。在这 10 个国家中,2010-2011 年(甲型 H1N1 2009pdm 大流行之后)私营部门的销售率超过了 2008 年大流行前的水平。有五个国家(印度尼西亚、马来西亚、新加坡、泰国和越南)制定了流感疫苗接种指南,但只有两个与全球指南一致。四个国家建议为卫生保健工作者接种疫苗,四个国家建议为老年人接种,三个国家建议为幼儿接种,三个国家建议为患有基础疾病者接种,两个国家建议为孕妇接种。
东南亚的疫苗销售量仍然较低,但在甲型 H1N1 2009pdm 大流行之后销售量有所增加。对全球疫苗指南的低遵从率表明,在政策领域还需要做更多的工作。