Medical Departments of Médecins Sans Frontières, Barcelona, Spain.
PLoS One. 2012;7(12):e52986. doi: 10.1371/journal.pone.0052986. Epub 2012 Dec 28.
A confirmed Ebola haemorrhagic fever (EHF) outbreak in Bundibugyo, Uganda, November 2007-February 2008, was caused by a putative new species (Bundibugyo ebolavirus). It included 93 putative cases, 56 laboratory-confirmed cases, and 37 deaths (CFR = 25%). Study objectives are to describe clinical manifestations and case management for 26 hospitalised laboratory-confirmed EHF patients. Clinical findings are congruous with previously reported EHF infections. The most frequently experienced symptoms were non-bloody diarrhoea (81%), severe headache (81%), and asthenia (77%). Seven patients reported or were observed with haemorrhagic symptoms, six of whom died. Ebola care remains difficult due to the resource-poor setting of outbreaks and the infection-control procedures required. However, quality data collection is essential to evaluate case definitions and therapeutic interventions, and needs improvement in future epidemics. Organizations usually involved in EHF case management have a particular responsibility in this respect.
2007 年 11 月至 2008 年 2 月，乌干达邦迪布焦暴发了一起埃博拉出血热（EHF）确诊疫情，由一种假定的新物种（邦迪布焦埃博拉病毒）引起。共报告了 93 例疑似病例，56 例实验室确诊病例，37 例死亡（病死率为 25%）。本研究的目的是描述 26 例住院治疗的实验室确诊埃博拉出血热患者的临床表现和病例管理。临床发现与先前报告的埃博拉出血热感染一致。最常经历的症状是非血性腹泻（81%）、严重头痛（81%）和乏力（77%）。7 名患者报告或观察到有出血症状，其中 6 人死亡。由于暴发时资源匮乏和需要感染控制程序，埃博拉护理仍然很困难。然而，为了评估病例定义和治疗干预措施，高质量的数据收集是必不可少的，在未来的疫情中需要加以改进。在这方面，通常参与埃博拉出血热病例管理的组织负有特殊责任。
