Director, Institute of Mental Health and Neurosciences, Kozhikode.
Indian J Psychiatry. 2005 Apr;47(2):121-3. doi: 10.4103/0019-5545.55961.
A benign pruritic rash occurs in 10%-15% of persons treated with carbamazepine. A small fraction of them may experience life-threatening dermatological syndromes such as exfoliative dermatitis, erythema multiforme, Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). The case of an 18-year-old female suffering from bipolar affective disorder (mania) who was being treated with carbamazepine, lithium, chlorpromazine and benzhexol is presented. After 10 days of treatment, she developed high-grade fever and mucocutaneous manifestations of SJS-TEN overlap. She was treated in hospital with systemic corticosteroids, antibiotics, intravenous fluids and other supportive measures, and recovered after 3 weeks.
约 10%-15%使用卡马西平治疗的患者会出现良性瘙痒性皮疹。其中一小部分患者可能会出现危及生命的皮肤综合征，如剥脱性皮炎、多形红斑、史蒂文斯-约翰逊综合征（SJS）和中毒性表皮坏死松解症（TEN）。本文报告了一例 18 岁女性患者，患有双相情感障碍（躁狂症），正在接受卡马西平、锂、氯丙嗪和苯海索治疗。治疗 10 天后，她出现高热和 SJS-TEN 重叠的黏膜皮肤表现。她在医院接受全身皮质类固醇、抗生素、静脉补液和其他支持性措施治疗，3 周后康复。
