Kumawat Ram Kumar, Kumar Suresh, Sharma Sunil
Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Haryana, India.
Acta Pol Pharm. 2012 Nov-Dec;69(6):1103-9.
Sida tiagii Bhandari mostly found in India and Pakistan which belongs to family Malvaceae, is traditionally used as analgesic, anti-inflammatory, sedative, anxiolytic, anti-seizure and anti-platelet. The present study was done to explore the analgesic activity of various extracts of fruits of the plant Sida tiagii Bhandari. The grinded fruits were extracted with 90% ethanol and partitioned with n-hexane (n-hexane extract; HS) and ethyl acetate (ethyl acetate extract; EAS), successively. The residual ethanol fraction (residual ethanol extract; RES) was also prepared by drying on water bath separately. All three extracts were administered orally at a dose of 200 mg/kg and 500 mg/kg of body weight. The analgesic activity of above extracts was evaluated by using acetic acid induced writhing, tail immersion and tail flick tests in Swiss albino mice. The EAS extract was found to reduce pain and RES extract of Sida tiagii B. was found to have good analgesic activity in comparison to other extracts.
蒂氏黄花稔主要分布于印度和巴基斯坦，属于锦葵科，传统上被用作镇痛药、抗炎药、镇静剂、抗焦虑药、抗惊厥药和抗血小板药。本研究旨在探讨蒂氏黄花稔果实不同提取物的镇痛活性。将研磨后的果实用90%乙醇提取，依次用正己烷（正己烷提取物；HS）和乙酸乙酯（乙酸乙酯提取物；EAS）进行分配。残留乙醇部分（残留乙醇提取物；RES）也通过在水浴上分别干燥制备。所有三种提取物均以200mg/kg和500mg/kg体重的剂量口服给药。通过在瑞士白化小鼠中进行醋酸诱导扭体、尾浸和甩尾试验来评估上述提取物的镇痛活性。结果发现，与其他提取物相比，EAS提取物能减轻疼痛，蒂氏黄花稔的RES提取物具有良好的镇痛活性。
