Mirna Moritz, Schmutzler Lukas, Topf Albert, Boxhammer Elke, Sipos Brigitte, Hoppe Uta C, Lichtenauer Michael
Department of Internal Medicine II, Division of Cardiology, Paracelsus Medical University of Salzburg, 5020 Salzburg, Austria.
J Cardiovasc Dev Dis. 2022 Jan 19;9(2):32. doi: 10.3390/jcdd9020032.
Previous animal studies reported an association of non-steroidal anti-inflammatory drugs (NSAIDs) with adverse outcomes in acute myocarditis, which is why these drugs are currently not recommended in affected patients. In this retrospective case-control study, we sought to investigate the effects of NSAID treatment in patients with acute myocarditis and myopericarditis to complement the available evidence. A total of 114 patients with acute myocarditis were retrospectively enrolled. Demographical, clinical and laboratory data were extracted from hospital records. Patients who received NSAIDs ( = 39, 34.2%) were compared to controls. Follow-up on all-cause mortality was acquired for two years. Propensity score matching was additionally conducted to account for covariate imbalances between groups. Treatment with NSAIDs was neither associated with a worse outcome ( = 0.115) nor with significant differences in left ventricular systolic function ( = 0.228) or in-hospital complications ( = 0.507). Treatment with NSAIDs was not associated with adverse outcomes in our study cohort. Together with the findings of previous studies, our results indicate that these drugs could be safely administered in patients with myocarditis and myopericarditis.
先前的动物研究报告了非甾体抗炎药（NSAIDs）与急性心肌炎不良结局之间的关联，这就是目前不建议在受影响患者中使用这些药物的原因。在这项回顾性病例对照研究中，我们试图调查NSAID治疗对急性心肌炎和心肌心包炎患者的影响，以补充现有证据。总共回顾性纳入了114例急性心肌炎患者。从医院记录中提取人口统计学、临床和实验室数据。将接受NSAIDs治疗的患者（n = 39，34.2%）与对照组进行比较。对全因死亡率进行了两年的随访。此外，还进行了倾向评分匹配，以解决组间协变量不平衡的问题。NSAIDs治疗既未与更差的结局相关（P = 0.115），也未与左心室收缩功能的显著差异（P = 0.228）或院内并发症相关（P = 0.507）。在我们的研究队列中，NSAIDs治疗与不良结局无关。结合先前研究的结果，我们的结果表明，这些药物可以在心肌炎和心肌心包炎患者中安全使用。
