将环状脲和 1-甲基-2-噁唑烷酮添加到吡啶中：一种合成吡啶并二氮杂卓、吡啶并二氮杂辛烷和吡啶并噁氮杂卓的新方法。
Addition of cyclic ureas and 1-methyl-2-oxazolidone to pyridynes: a new approach to pyridodiazepines, pyridodiazocines, and pyridooxazepines.
机构信息
Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.
出版信息
Org Lett. 2013 Jan 18;15(2):386-9. doi: 10.1021/ol303352q. Epub 2013 Jan 3.
PMID:23286344
Abstract
Reactions of pyridynes with cyclic urea and 1-methyl-2-oxazolidone were demonstrated. 3,4-Pyridyne and 2,3-pyridyne were reacted with N,N-dimethylimidazolidone, N,N-dimethylpropylene urea, and 1-methyl-2-oxazolidone to give the corresponding pyridodiazepines, pyridodiazocines, and pyridooxazepines, respectively.
摘要
展示了吡啶与环状尿素和 1-甲基-2-噁唑烷酮的反应。3,4-吡啶和 2,3-吡啶分别与 N,N-二甲基咪唑烷酮、N,N-二甲基丙烯脲和 1-甲基-2-噁唑烷酮反应，分别得到相应的吡啶二氮杂环庚烷、吡啶二氮杂环辛烷和吡啶噁唑烷。
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