Department of Medicine, Medical University of South Carolina, 135 Rutledge Ave, Rm 1224, Charleston, SC 29425, USA.
Am J Manag Care. 2012 Dec 1;18(12):e461-7.
To evaluate the association between social support and medication adherence.
A search of articles published before November 2010 in peer-reviewed, healthcare-related journals was conducted using PubMed, EMBASE, and Web of Science, and search terms related to social support (social support OR friend OR family OR agency) and adherence (patient compliance OR medication adherence), yielding 5331 articles.
Articles were included if they directly measured the relationship between medication adherence and some form of social support. Excluded were case studies, studies with participants < 18 years of age, and non-English language studies. Four social support categories were reported: structural, practical, emotional, and combination. Medication adherence was reported in the manner in which it was described in each study.
Fifty studies were included in the final analysis. A greater degree of practical support was most consistently associated with greater adherence to medication; evidence for structural or emotional support was less compelling. However, most studies were limited in size and design, and substantial variability in designs and outcome measurement prohibited pooling of results, necessitating qualitative evaluation of the studies.
This qualitative analysis found that practical social support was most consistently associated with greater medication adherence. Interventions that use existing contacts (friends or family) to engage patients in the mundane and practical aspects of medication purchasing and administration may be an effective approach to promoting better medication adherence.
评估社会支持与药物依从性之间的关系。
使用 PubMed、EMBASE 和 Web of Science 对 2010 年 11 月之前在同行评审的医疗保健相关期刊上发表的文章进行了检索，检索词与社会支持（社会支持、朋友、家庭、机构）和依从性（患者依从性、药物依从性）相关，共检索到 5331 篇文章。
如果文章直接测量了药物依从性与某种形式的社会支持之间的关系，则将其纳入。排除病例研究、参与者年龄<18 岁的研究以及非英语语言的研究。报告了四种社会支持类别：结构、实用、情感和组合。药物依从性以每项研究中描述的方式报告。
最终分析包括 50 项研究。更多的实际支持与更高的药物依从性最一致相关；结构或情感支持的证据不太令人信服。然而，大多数研究的规模和设计有限，设计和结果测量的显著差异使得结果无法合并，需要对研究进行定性评估。
这项定性分析发现，实际的社会支持与更高的药物依从性最一致相关。利用现有的联系人（朋友或家人）使患者参与药物购买和管理的平凡和实际方面的干预措施可能是促进更好药物依从性的有效方法。
