线粒体靶向抗氧化剂SkQ1和肉苁蓉的治疗效果与大鼠晶状体中色氨酸和犬尿氨酸水平升高有关。
The therapeutic effect of mitochondria-targeted antioxidant SkQ1 and Cistanche deserticola is associated with increased levels of tryptophan and kynurenine in the rat lens.
作者信息
Snytnikova O A, Tsentalovich Yu P, Stefanova N A, Fursova A Zh, Kaptein R, Sagdeev R Z, Kolosova N G
机构信息
International Tomography Center of the Siberian Branch of Russian Academy of the Sciences, Novosibirsk State University, Novosibirsk, Russia.
出版信息
Dokl Biochem Biophys. 2012 Nov-Dec;447:300-3. doi: 10.1134/S1607672912060087. Epub 2013 Jan 4.
Supplementation of senescence-accelerated OXYS rats with the mitochondria-targeted antioxidant SkQ1 and with the powder from Cistanche deserticola results in the deceleration of the cataract development and even in the improvement of lens transparency. The therapeutic effect of these preparations correlates with a significant elevation of tryptophan and kynurenine levels in the lens. This finding is attributed to a deceleration of the tryptophan and kynurenine oxidation due to antioxidant-assisted reduction of oxidative stress in the lens.
给衰老加速的OXYS大鼠补充线粒体靶向抗氧化剂SkQ1和肉苁蓉粉，可减缓白内障的发展，甚至改善晶状体透明度。这些制剂的治疗效果与晶状体中色氨酸和犬尿氨酸水平的显著升高相关。这一发现归因于抗氧化剂辅助降低晶状体氧化应激，从而减缓了色氨酸和犬尿氨酸的氧化。
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