Hudgens Joshua L, Gillette Blake P, Krych Aaron J, Stuart Michael J, May Jedediah H, Levy Bruce A
Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN, USA.
J Knee Surg. 2013 Apr;26(2):109-15. doi: 10.1055/s-0032-1319778. Epub 2012 Jun 28.
Controversy exists as to the superior graft source for posterior cruciate ligament (PCL) reconstruction. Allogeneic and autogeneic tissue have unique advantages and disadvantages, but little is known about the performance of one versus the other. This study is an evidence-based, systematic literature review comparing clinical and functional outcomes of allograft and autograft PCL reconstruction. A search was conducted via the Cochrane and MEDLINE databases for all relevant studies meeting the following inclusion criteria: (1) English language, (2) human subjects, (3) between the years 1980 and 2011, (4) minimum 24-month follow-up, (5) measures of clinical and functional outcomes, and (6) patients with isolated grade II/III PCL injuries who had failed nonoperative management and were deemed clinically and functionally unstable. Excluded studies were (1) technique articles, (2) case reports, and (3) patients with additional ligamentous or bony injuries. A total of 19 relevant studies were identified (2 direct comparison, 5 allograft, and 12 autograft). No appreciable differences between allograft and autograft PCL reconstruction were identified. A paucity of data exists comparing allogeneic and autogeneic PCL reconstruction, but satisfactory clinical and functional results have been obtained with both graft sources.
关于后交叉韧带（PCL）重建的最佳移植物来源存在争议。同种异体组织和自体组织都有其独特的优缺点，但对于两者的性能了解甚少。本研究是一项基于证据的系统文献综述，比较同种异体移植物和自体移植物PCL重建的临床和功能结果。通过Cochrane和MEDLINE数据库对所有符合以下纳入标准的相关研究进行检索：（1）英文文献；（2）人类受试者；（3）1980年至2011年期间；（4）至少24个月的随访；（5）临床和功能结果的测量；（6）孤立性II/III级PCL损伤且非手术治疗失败、临床和功能上不稳定的患者。排除的研究包括：（1）技术文章；（2）病例报告；（3）伴有其他韧带或骨损伤的患者。共确定了19项相关研究（2项直接比较、5项同种异体移植物和12项自体移植物）。未发现同种异体移植物和自体移植物PCL重建之间存在明显差异。比较同种异体和自体PCL重建的数据较少，但两种移植物来源均取得了令人满意的临床和功能结果。
