Coe J E, Ishak K G, Ross M J
National Institutes of Health, NIAID, Rocky Mountain Laboratories, Hamilton, Montana 59840.
Hepatology. 1990 Apr;11(4):570-7. doi: 10.1002/hep.1840110408.
Liver tumors were found in most Armenian hamsters (Cricetulus migratorius) injected with on 15-mg pellet of diethylstilbestrol. The tumors were detectable as early as 1 1/2 mo after diethylstilbestrol administration and were usually present as multiple nodules that progressively increased in size. Histologically, the multicentric neoplasms were all hepatocellular carcinomas of varied degrees of differentiation and frequently (42.8%) contained Mallory bodies; preneoplastic lesions were not observed. This hepatocellular carcinoma hamster model is unique because estrogen alone without any other known mutagen is responsible for induction of hepatocellular carcinoma.
在大多数注射了15毫克己烯雌酚丸粒的亚美尼亚仓鼠（黑线仓鼠）中发现了肝脏肿瘤。这些肿瘤在给予己烯雌酚后最早1个半月就可检测到，通常表现为多个结节，且大小逐渐增加。组织学上，多中心肿瘤均为不同分化程度的肝细胞癌，且经常（42.8%）含有马洛里小体；未观察到癌前病变。这种肝细胞癌仓鼠模型很独特，因为仅雌激素在没有任何其他已知诱变剂的情况下就能诱导肝细胞癌。
