Bell R H, Hye R J, Miyai K
Carcinogenesis. 1984 Oct;5(10):1235-8. doi: 10.1093/carcin/5.10.1235.
Streptozotocin was administered in a dose of 50 mg/kg body weight intraperitoneally on three consecutive days to 35 8-week old male Syrian golden hamsters. At sacrifice 16-36 weeks later, macroscopic liver tumors had developed in 27 of 29 surviving animals. The majority of animals had multiple hepatic nodules. Some tumors were already large (greater than 1 cm) 16 weeks after streptozotocin. By histologic criteria, five animals (17%) had hepatocellular carcinoma, 23 (79%) had adenomas with varying degrees of atypia, and one (4%) had a normal liver. No metastases to organs outside the liver were noted. No other primary tumors were observed. Sixteen of 29 animals had ascites. Twenty-five age-matched untreated animals showed no evidence of liver tumors. Although sporadic liver tumors due to streptozotocin have been reported in rats and mice, the high incidence of tumors and short latency period to tumor induction seem to be unique to the Syrian hamster. The development of liver carcinoma without the necessity for long-term administration of the carcinogen and without adjunctive procedures such as partial hepatectomy represents a potential improvement over other animal models of hepatic neoplasia.
对35只8周龄的雄性叙利亚金黄地鼠连续三天腹腔注射链脲佐菌素，剂量为50毫克/千克体重。在16至36周后处死动物时，29只存活动物中有27只出现了肉眼可见的肝肿瘤。大多数动物有多个肝结节。链脲佐菌素注射16周后，一些肿瘤已经很大（大于1厘米）。根据组织学标准，5只动物（17%）患有肝细胞癌，23只（79%）患有不同程度异型性的腺瘤，1只（4%）肝脏正常。未发现肝外器官转移。未观察到其他原发性肿瘤。29只动物中有16只有腹水。25只年龄匹配的未治疗动物未显示肝肿瘤迹象。尽管在大鼠和小鼠中已有链脲佐菌素导致散发性肝肿瘤的报道，但肿瘤的高发生率和较短的诱导潜伏期似乎是叙利亚地鼠所特有的。无需长期给予致癌物且无需如部分肝切除术等辅助程序即可发生肝癌，这相对于其他肝肿瘤动物模型而言是一种潜在的改进。
