College of Pharmacy, Sunchon National University, Sunchon, Jeonnam, 540-950, Republic of Korea.
J Chromatogr A. 2013 Jan 25;1274:1-5. doi: 10.1016/j.chroma.2012.11.086. Epub 2012 Dec 10.
Chiral crown ethers have been widely used in the resolution of various chiral compounds containing a primary amino group. Covalently bonded chiral stationary phases derived from (18-crown-6)-2,3,11,12-tetracarboxylic acid (18-C-6-TA) were developed in our groups and utilized for the resolution for several types of analytes. By use of NMR spectroscopy, chiral discrimination studies were performed for α-amino acids and their esters using 18-C-6-TA. Here, advances in the development and application of chiral stationary phases and chiral solvating agents using 18-C-6-TA for enantiomer resolution are described in relationship to recent chiral recognition mechanism studies.
手性冠醚在拆分各种含伯氨基的手性化合物方面得到了广泛的应用。本课题组开发了基于（18-冠-6）-2,3,11,12-四羧酸（18-C-6-TA）的共价键合手性固定相，并将其用于多种分析物的拆分。通过 NMR 光谱法，使用 18-C-6-TA 对 α-氨基酸及其酯进行了手性识别研究。本文在手性识别机制研究的基础上，介绍了 18-C-6-TA 在手性固定相和手性溶剂添加剂的发展和应用方面的最新进展。
