School of Chemistry and Molecular Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.
Colloids Surf B Biointerfaces. 2013 Apr 1;104:326-9. doi: 10.1016/j.colsurfb.2012.11.033. Epub 2012 Dec 7.
Liposomes with superparamagnetic iron oxide nanoparticles embedded in membrane were prepared by the supercritical carbon dioxide (scCO(2)) method. The cargos can be released from liposomes by both triggered agents, temperature and alternating current electromagnetic field (AMF). The release mechanism was explained from the view of microstructure change investigated by fluorescence probe method. The contents could be repetitively released from liposomes controlled by switching on and off the AMF. The results indicated that the release from the liposomes was due to the magnetocaloric effect resulting in the liposome phase transition and the magnetic-impelled motions leading to the improved bilayer permeability, rather than the destruction of the liposome structure.
通过超临界二氧化碳（scCO2）方法制备了嵌入在膜中的超顺磁性氧化铁纳米粒子的脂质体。通过触发剂、温度和交流电磁场（AMF）可以将货物从脂质体中释放出来。通过荧光探针法研究的微观结构变化来解释释放机制。通过打开和关闭 AMF 来控制脂质体，可以重复地从脂质体中释放出内容物。结果表明，脂质体的释放是由于磁热效应导致脂质体相变，以及磁推动运动导致双层通透性提高，而不是脂质体结构的破坏。
