Department of Drug Sciences, Section of Biochemistry, University of Catania, V.le A. Doria 6, 95125 Catania, Italy.
Food Chem Toxicol. 2013 May;55:42-7. doi: 10.1016/j.fct.2012.12.036. Epub 2013 Jan 2.
Salvia officinalis L. can be found worldwide and its leaves are commonly used as ingredient in food industry. Sage essential oil is applied in the treatment of a range of diseases and has been shown to possess different biological activities. The objectives of our research were to study the effects of environment on crop, chemical composition and anticancer activity on S. officinalis essential oil. Sage was cultivated at eighteen experimental sites in south-central Italy (Molise) in different growing environments. The essential oils (S1-S18), extracted by hydrodistillation, were analyzed by GC and CG/MS. Results show that the main components were α-thujone, camphor, borneol, γ-muurolene and sclareol for all the samples, but the percentages of these compounds varied depending on environmental factors such as altitude, water availability and pedo-climatic conditions. The growth-inhibitory and proapoptotic effects of the eighteen sage essential oils were evaluated in three human melanoma cell lines, A375, M14, and A2058.
迷迭香在世界各地都有发现，其叶子通常被用作食品工业的成分。鼠尾草精油在治疗多种疾病方面有应用，并表现出不同的生物活性。我们的研究目的是研究环境对作物、化学成分和迷迭香精油抗癌活性的影响。迷迭香在意大利中南部（莫利塞）的十八个实验点种植，生长环境不同。通过水蒸馏提取的精油（S1-S18）通过 GC 和 CG/MS 进行分析。结果表明，所有样品的主要成分均为α-侧柏酮、樟脑、龙脑、γ-杜松烯和石竹烯，但这些化合物的百分比因海拔、水分供应和土壤气候条件等环境因素而异。在三种人黑色素瘤细胞系 A375、M14 和 A2058 中，评估了这 18 种迷迭香精油的生长抑制和促凋亡作用。
