Kucukkurt Ismail, Akbel Erten, Karabag Funda, Ince Sinan
Department of Biochemistry, Faculty of Veterinary Medicine, Afyon Kocatepe University, Afyonkarahisar, Turkey
Usak University, Usak Health Training School, Uşak, Turkey.
Toxicol Ind Health. 2015 Mar;31(3):255-60. doi: 10.1177/0748233712469648. Epub 2013 Jan 4.
The aims of this study were to clarify the effects of dietary boric acid or borax, as a boron (B) source, on hormonal status (leptin, insulin, triiodothyronine (T3), and thyroxine) and some biochemical parameter levels as glucose, carnitine, nonesterified fatty acids, and betahydroxybutyric acid in rats. A total of 30 Sprague-Dawley male rats were divided into three equal groups: the animals in the first group (control) were fed with a standard rodent diet containing 6.4 mg B/kg, and the animals in the experimental group were fed with a standard rodent diet added with boric acid and borax (100 mg B/kg) throughout the experimental period of 28 days. The B compounds especially borax decreased leptin, insulin, and glucose levels, whereas increased T3 and carnitine levels in plasma. In addition, body weight of rats was found to be low in the boric acid group at the end of 4 weeks. Consequently, our results demonstrate that B supplementation (100 mg/kg) in diet decreases body weight, leptin, and insulin, whereas increases T3 levels in plasma, so enhances the metabolic activity of rats. Between the B compounds used in this study, it was found that borax had a greater effect on hormonal status than boric acid.
本研究的目的是阐明作为硼（B）源的膳食硼酸或硼砂对大鼠激素状态（瘦素、胰岛素、三碘甲状腺原氨酸（T3）和甲状腺素）以及一些生化参数水平（如葡萄糖、肉碱、非酯化脂肪酸和β-羟基丁酸）的影响。总共30只Sprague-Dawley雄性大鼠被分为三组，每组数量相等：第一组（对照组）的动物喂食含6.4 mg B/kg的标准啮齿动物饲料，实验组的动物在整个28天的实验期内喂食添加了硼酸和硼砂（100 mg B/kg）的标准啮齿动物饲料。硼化合物尤其是硼砂降低了瘦素、胰岛素和葡萄糖水平，而提高了血浆中T3和肉碱水平。此外，在4周结束时发现硼酸组大鼠的体重较低。因此，我们的结果表明，饮食中补充硼（100 mg/kg）可降低体重、瘦素和胰岛素水平，而提高血浆中T3水平，从而增强大鼠的代谢活性。在本研究中使用的硼化合物之间，发现硼砂对激素状态的影响比硼酸更大。
