Departments of Chemistry, Division of Biochemistry, Faculty of Science and Letter, Kafkas University, Kars, Turkey.
Department of Pharmacy Services, Tuzluca Vocational High School, Igdır University, Igdır-Turkey.
Int J Vitam Nutr Res. 2020 Jun;90(3-4):221-227. doi: 10.1024/0300-9831/a000518. Epub 2019 Feb 12.
The aim of this study was to investigate the effects of boric acid (BA) and borax (BX) on live weight and obesity associated molecules including leptin, L-carnitine, insulin-like growth factor 1 (IGF-I), and heat shock proteins 70 (HSP70) in rats fed with high-fat diet. A total of 60 rats were equally allocated as ND (normal diet), HF (high-fat diet), HF+BA, HF+BX, ND+BX, ND+BA. Body weight increases in HF+BA (85 g) and HF+BX (86 g) were significantly lower (p<0.05) compared to HF group (126 g). Boron treatment decreased serum L-carnitine level in high-fat diet (HF+BA 11.12 mg/L, HF+BX 10.51 mg/L, p<0.05) compared to HF group (15.57 mg/L), while no change was observed in groups ND+BA (7.55 mg/L) and ND+BX (7.57 mg/L) compared to group ND (8.29 mg/L). Neither BA nor BX supplementation in ND and HF groups altered the serum levels of HSP70 and leptin. BA and BX supplementation in rats fed HF resulted in a significant reduction in live weight. Boron compounds altered L-carnitine and IGF-1 levels in rats. These results indicate that boron compounds are beneficial in the treatment of obesity as well as in the prevention of high-fat diet-induced weight increase. Alterations in serum L-carnitine and IGF-1 levels in boron treated rats also indicate possible role of boron compounds in energy metabolism in response to high fat diet.
本研究旨在探讨硼酸（BA）和硼砂（BX）对高脂肪饮食喂养大鼠体重和肥胖相关分子（包括瘦素、L-肉碱、胰岛素样生长因子 1（IGF-1）和热休克蛋白 70（HSP70））的影响。将 60 只大鼠等分为 ND（正常饮食）、HF（高脂肪饮食）、HF+BA、HF+BX、ND+BX 和 ND+BA。与 HF 组（126 g）相比，HF+BA（85 g）和 HF+BX（86 g）的体重增加明显较低（p<0.05）。硼处理降低了高脂肪饮食中血清 L-肉碱水平（HF+BA 为 11.12 mg/L，HF+BX 为 10.51 mg/L，p<0.05），而 ND+BA（7.55 mg/L）和 ND+BX（7.57 mg/L）组与 ND 组（8.29 mg/L）相比没有变化。ND 和 HF 组中 BA 和 BX 的补充均未改变 HSP70 和瘦素的血清水平。HF 喂养大鼠中 BA 和 BX 的补充导致体重显著减轻。硼化合物改变了高脂肪饮食喂养大鼠的 L-肉碱和 IGF-1 水平。这些结果表明，硼化合物在肥胖治疗以及预防高脂肪饮食引起的体重增加方面是有益的。硼处理大鼠血清 L-肉碱和 IGF-1 水平的改变也表明硼化合物在应对高脂肪饮食时可能在能量代谢中发挥作用。
