来自于内生真菌菰米小丛壳的芦竹醇 A-C 和菰酮 A、B。

Arundinols A-C and arundinones A and B from the plant endophytic fungus Microsphaeropsis arundinis.

机构信息

State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100190, People's Republic of China.

出版信息

J Nat Prod. 2013 Jan 25;76(1):107-12. doi: 10.1021/np300806a. Epub 2013 Jan 7.

DOI:10.1021/np300806a

PMID:23294378

Abstract

Three new ent-eudesmane sesquiterpenoids, arundinols A-C (1-3), one isochroman-1-one, arundinone A (4), and a polyoxygenated benzofuran-3(2H)-one dimer, arundinone B (5), were isolated from the extract of a plant endophytic fungus, Microsphaeropsis arundinis. Their structures were elucidated primarily by NMR experiments, and 1 was confirmed by X-ray crystallography. The absolute configuration of 1 was assigned by X-ray crystallography using Cu Kα radiation, whereas those of the C-11 tertiary alcohols in 2 and 3 were deduced via the circular dichroism data of the in situ formed [Rh(2)(OCOCF(3))(4)] complexes. Arundinone B (5) represents the first dimeric benzofuran-3(2H)-one, showing cytotoxicity against T24 and A549 cells. The co-isolated known compound 6 showed a modest inhibitory effect against Staphylococcus aureus.

摘要

从植物内生真菌 Microsphaeropsis arundinis 的提取物中分离得到三种新的桉烷倍半萜，即 arundinol A-C（1-3）、isochroman-1-one、arundinone A（4）和一种多氧化苯并呋喃-3(2H)-one 二聚体 arundinone B（5）。它们的结构主要通过 NMR 实验阐明，1 则通过 X 射线晶体学确定。1 的绝对构型通过 X 射线晶体学使用 Cu Kα 辐射确定，而 2 和 3 中 C-11 叔醇的构型则通过原位形成的[Rh(2)(OCOCF(3))(4)]络合物的圆二色谱数据推断。arundinone B（5）代表第一个苯并呋喃-3(2H)-one 二聚体，对 T24 和 A549 细胞具有细胞毒性。共分离得到的已知化合物 6 对金黄色葡萄球菌表现出适度的抑制作用。