Kolodzinskyi Michail N, Zhao Chunfeng, Sun Yu-Long, An Kai-Nan, Thoreson Andrew R, Amadio Peter C, Moran Steven L
Biomechanics Laboratory, Division of Orthopedics Research, Mayo Clinic, Rochester, Minnesota 55905, USA.
J Hand Surg Am. 2013 Feb;38(2):231-6. doi: 10.1016/j.jhsa.2012.11.012. Epub 2013 Jan 5.
Studies have shown that a lubricant exogenously applied on extrasynovial tendon surfaces can reduce the gliding resistance after flexor tendon repair; however, the reagents that have been tested are solely for experimental testing and are not available for clinical use. The purpose of this study was to investigate the effect of exogenously applied hylan G-F 20, a U.S. Food and Drug Administration-approved hyaluronic acid for the treatment of osteoarthritis, on extrasynovial tendon gliding resistance in an in vitro canine model.
Twenty-four canine peroneus longus (PL) tendons and proximal pulleys of the ipsilateral paws were treated with 1 of 3 solutions: saline, carbodiimide derivatized hylan G-F 20, or unmodified hylan G-F 20. The gliding resistance of each tendon preparation was then measured over 1000 cycles in a saline bath.
After 1,000 cycles, the gliding resistance of the PL tendons treated with unmodified hylan G-F 20 decreased significantly compared with the saline-treated tendons. The gliding resistance of the PL tendons treated with modified hylan G-F 20 increased significantly compared with the saline group.
The PL tendons treated with pure hylan G-F 20 showed a positive effect on the gliding resistance.
The results of this in vitro canine study suggest that exogenously applied hylan G-F 20 improves gliding of the extrasynovial tendon graft. This material may be capable of reducing friction over flexor tendon repair sites and flexor tendon grafts.
研究表明，外源性应用于滑膜外肌腱表面的润滑剂可降低屈肌腱修复后的滑动阻力；然而，已测试的试剂仅用于实验测试，无法用于临床。本研究的目的是在体外犬模型中研究外源性应用的hylan G-F 20（一种经美国食品药品监督管理局批准用于治疗骨关节炎的透明质酸）对滑膜外肌腱滑动阻力的影响。
将24条犬的腓骨长肌（PL）肌腱和同侧爪子的近端滑车用3种溶液中的1种进行处理：生理盐水、碳二亚胺衍生化的hylan G-F 20或未修饰的hylan G-F 20。然后在盐浴中对每个肌腱制剂的滑动阻力进行1000个循环的测量。
1000个循环后，与生理盐水处理的肌腱相比，未修饰的hylan G-F 20处理的PL肌腱的滑动阻力显著降低。与生理盐水组相比，修饰的hylan G-F 20处理的PL肌腱的滑动阻力显著增加。
用纯hylan G-F 20处理的PL肌腱对滑动阻力有积极影响。
这项体外犬研究的结果表明，外源性应用hylan G-F 20可改善滑膜外肌腱移植物的滑动。这种材料可能能够减少屈肌腱修复部位和屈肌腱移植物上的摩擦。
