2012 年的肾血管炎：再分类和生物制剂的引入。
Renal vasculitis in 2012: reclassification and the introduction of biologicals.
机构信息
Department of Rheumatology & Clinical Immunology, University of Groningen, University Medical Center Groningen, PO Box 30.001, 9700 RB Groningen, The Netherlands.
出版信息
Nat Rev Nephrol. 2013 Feb;9(2):70-2. doi: 10.1038/nrneph.2012.284. Epub 2013 Jan 8.
2012 saw the classification of the systemic vasculitides revised. Genetic studies showed that granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA) are different diseases with aberrant immune responses to different autoantigens. B-cell depletion with rituximab also acquired a primary role in the treatment of GPA and MPA, as well as in cryoglobulinaemic vasculitis.
2012 年，系统性血管炎的分类得到了修订。遗传研究表明，肉芽肿性多血管炎（GPA）和显微镜下多血管炎（MPA）是两种不同的疾病，它们对不同的自身抗原有异常的免疫反应。利妥昔单抗清除 B 细胞也在 GPA 和 MPA 的治疗以及冷球蛋白血症性血管炎中发挥了主要作用。
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