Laboratoire d'Ecologie Alpine, UMR 5553, CNRS- Université de Grenoble, BP 53, 38041 Grenoble cedex 09, France.
Philos Trans R Soc Lond B Biol Sci. 2013 Jan 6;368(1612):20120429. doi: 10.1098/rstb.2012.0429. Print 2013 Feb 19.
The fight against diseases spread by mosquitoes and other insects has enormous environmental, economic and social consequences. Chemical insecticides remain the first line of defence but the control of diseases, especially malaria and dengue fever, is being increasingly undermined by insecticide resistance. Mosquitoes have a large repertoire of P450s (over 100 genes). By pinpointing the key enzymes associated with insecticide resistance we can begin to develop new tools to aid the implementation of control interventions and reduce their environmental impact on Earth. Recent technological advances are helping us to build a functional profile of the P450 determinants of insecticide metabolic resistance in mosquitoes. Alongside, the cross-responses of mosquito P450s to insecticides and pollutants are also being investigated. Such research will provide the means to produce diagnostic tools for early detection of P450s linked to resistance. It will also enable the design of new insecticides with optimized efficacy in different environments.
与蚊子和其他昆虫传播的疾病作斗争具有巨大的环境、经济和社会影响。化学杀虫剂仍然是第一道防线，但疾病的控制，特别是疟疾和登革热，正越来越受到杀虫剂耐药性的破坏。蚊子拥有大量的 P450s（超过 100 个基因）。通过确定与杀虫剂耐药性相关的关键酶，我们可以开始开发新的工具来帮助实施控制干预措施，并减少它们对地球环境的影响。最近的技术进步正在帮助我们构建蚊子中杀虫剂代谢耐药性的 P450 决定因素的功能图谱。与此同时，蚊子 P450 对杀虫剂和污染物的交叉反应也在被研究。此类研究将为生产与耐药性相关的 P450 早期检测诊断工具提供手段。它还将使设计在不同环境中具有优化功效的新型杀虫剂成为可能。
