Qi Zhifeng, Liu Wenlan, Luo Yumin, Ji Xunming, Liu Ke Jian
Cerebrovascular Diseases Research Institute, Xuanwu Hospital of Capital Medical University, No,45 Changchun Street, Beijing, 100053, China.
Med Gas Res. 2013 Jan 9;3(1):2. doi: 10.1186/2045-9912-3-2.
Stroke is a leading cause of death and disability due to disturbance of blood supply to the brain. As brain is highly sensitive to hypoxia, insufficient oxygen supply is a critical event contributing to ischemic brain injury. Normobaric hyperoxia (NBO) that aims to enhance oxygen delivery to hypoxic tissues has long been considered as a logical neuroprotective therapy for ischemic stroke. To date, many possible mechanisms have been reported to elucidate NBO's neuroprotection, such as improving tissue oxygenation, increasing cerebral blood flow, reducing oxidative stress and protecting the blood brain barrier. As ischemic stroke triggers a battery of damaging events, combining NBO with other agents or treatments that target multiple mechanisms of injury may achieve better outcome than individual treatment alone. More importantly, time loss is brain loss in acute cerebral ischemia. NBO can be a rapid therapy to attenuate or slow down the evolution of ischemic tissues towards necrosis and therefore "buy time" for reperfusion therapies. This article summarizes the current literatures on NBO as a simple, widely accessible, and potentially cost-effective therapeutic strategy for treatment of acute ischemic stroke.
中风是由于脑部血液供应紊乱导致死亡和残疾的主要原因。由于大脑对缺氧高度敏感，氧气供应不足是导致缺血性脑损伤的关键因素。旨在增强向缺氧组织输送氧气的常压高氧疗法（NBO）长期以来一直被视为缺血性中风合理的神经保护疗法。迄今为止，已报道了许多可能的机制来阐明NBO的神经保护作用，如改善组织氧合、增加脑血流量、减少氧化应激和保护血脑屏障。由于缺血性中风会引发一系列破坏性事件，将NBO与针对多种损伤机制的其他药物或治疗方法联合使用可能比单独使用个体治疗取得更好的效果。更重要的是，在急性脑缺血中，时间损失即脑损伤。NBO可以作为一种快速疗法来减轻或减缓缺血组织向坏死的演变，从而为再灌注疗法“争取时间”。本文总结了关于NBO作为一种治疗急性缺血性中风的简单、广泛可用且可能具有成本效益的治疗策略的当前文献。
